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Tbio
ALKBH2
DNA oxidative demethylase ALKBH2

Protein Summary
Description
Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343075
  • ENSP00000343021
  • ENSG00000189046
  • ENST00000429722
  • ENSP00000398181
  • ENST00000440112
  • ENSP00000399820
  • ENST00000619381
  • ENSP00000478765

Symbol
  • ABH2
  • ABH2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.82
cell type or tissue
0.72
molecular function
0.63
histone modification site profile
0.5
virus perturbation
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.47   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.47   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
SYNJ1
Tchem
Novelty:  0.01030746
p_int:  0.999999683
p_ni:  3.17e-7
Score:  0.252
Data Source:  BioPlex,STRINGDB
CCDC151
Tbio
Novelty:  0.15952702
p_int:  0.999998692
p_ni:  3.3e-8
p_wrong:  0.000001274
Score:  0.188
Data Source:  BioPlex,STRINGDB
AARSD1
Tdark
Novelty:  0.75372406
p_int:  0.999670855
p_ni:  0.000085112
p_wrong:  0.000244033
Score:  0.181
Data Source:  BioPlex,STRINGDB
LCN15
Tdark
Novelty:  0.54935158
p_int:  0.998842992
p_ni:  0.000057492
p_wrong:  0.001099516
Score:  0.455
Data Source:  BioPlex,STRINGDB
ALKBH1
Tbio
Family:  Enzyme
Novelty:  0.00504781
Score:  0.908
Data Source:  STRINGDB
ALKBH8
Tbio
Novelty:  0.02797162
Score:  0.894
Data Source:  STRINGDB
FTO
Tchem
Family:  Enzyme
Novelty:  0.00053473
Score:  0.812
Data Source:  STRINGDB
JMJD4
Tbio
Novelty:  0.09951585
Score:  0.8
Data Source:  STRINGDB
ALKBH5
Tbio
Family:  Enzyme
Novelty:  0.01158189
Score:  0.795
Data Source:  STRINGDB
ALKBH4
Tbio
Family:  Enzyme
Novelty:  0.34513259
Score:  0.738
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
ALKBH2 mediated reversal of alkylation damage (R-HSA-112122)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ALKBH2 mediated reversal of alkylation damage
Reactome
DNA Damage Reversal
Reactome
DNA Repair
Reactome
Reversal of alkylation damage by DNA dioxygenases
Name
Explore in Pharos
Explore in Source
ALKBH2 mediated reversal of alkylation damage
DNA Damage Reversal
DNA Repair
Reversal of alkylation damage by DNA dioxygenases
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
2
2
95.3
platelet count
2
2
2
94.8
mitochondrial DNA measurement
1
1
1
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
95.3
platelet count
2
94.8
mitochondrial DNA measurement
1
57.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
alkB homolog 2, alpha-ketoglutarate dependent dioxygenase
VGNC:4918
107967636
Mouse
MGI:2141032
231642
Rat
RGD:1306377
304578
Dog
alkB homolog 2, alpha-ketoglutarate dependent dioxygenase
VGNC:37803
477524
Horse
alkB homolog 2, alpha-ketoglutarate dependent dioxygenase
VGNC:15254
100059785
Species
Name
OMA
EggNOG
Inparanoid
Chimp
alkB homolog 2, alpha-ketoglutarate dependent dioxygenase
Mouse
Rat
Dog
alkB homolog 2, alpha-ketoglutarate dependent dioxygenase
Horse
alkB homolog 2, alpha-ketoglutarate dependent dioxygenase
Publication Statistics
PubMed Score 42.47
PubMed score by year
PubTator Score 30.65
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title