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Tbio
TET2
Methylcytosine dioxygenase TET2

Protein Summary
Description
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The enc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265149
  • ENSP00000265149
  • ENSG00000168769
  • ENST00000305737
  • ENSP00000306705
  • ENST00000380013
  • ENSP00000369351
  • ENST00000540549
  • ENSP00000442788

Symbol
  • KIAA1546
  • MDS
  • KIAA1546
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.88
biological term
0.85
microRNA
0.83
transcription factor
0.78
transcription factor perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 862.76   (req: < 5)
Gene RIFs: 223   (req: <= 3)
Antibodies: 416   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 862.76   (req: >= 5)
Gene RIFs: 223   (req: > 3)
Antibodies: 416   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (64)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
7
21
11
6.4
93.5
lymphocyte count
4
3
4
93.5
7
3
1
1.1
93.2
self reported educational attainment
5
5
4
6.9
93
body height
3
3
3
92.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
11
6.4
93.5
lymphocyte count
4
93.5
1
1.1
93.2
self reported educational attainment
4
6.9
93
body height
3
92.7
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tet methylcytosine dioxygenase 2
VGNC:730
471263
Mouse
MGI:2443298
214133
Rat
RGD:1311625
310859
Dog
tet methylcytosine dioxygenase 2
VGNC:47261
478499
Cow
tet methylcytosine dioxygenase 2
VGNC:35757
538481
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tet methylcytosine dioxygenase 2
Mouse
Rat
Dog
tet methylcytosine dioxygenase 2
Cow
tet methylcytosine dioxygenase 2
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q6N021-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Epigenetic regulation of gene expression (R-HSA-212165)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
TET1,2,3 and TDG demethylate DNA
Name
Explore in Pharos
Explore in Source
Epigenetic regulation of gene expression
Gene expression (Transcription)
TET1,2,3 and TDG demethylate DNA
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (125)
1 – 10 of 125
NONO
Tbio
Novelty:  0.00501502
p_int:  0.99999647
p_ni:  0.000003454
p_wrong:  7.5e-8
Score:  0.335
Data Source:  BioPlex,STRINGDB
NUP62CL
Tdark
Novelty:  2.93223607
p_int:  0.999975413
p_ni:  0.000004204
p_wrong:  0.000020383
Data Source:  BioPlex
SEMG1
Tbio
Novelty:  0.0161449
p_int:  0.993702609
p_ni:  0.006296927
p_wrong:  4.64e-7
Score:  0.219
Data Source:  BioPlex,STRINGDB
ASXL1
Tbio
Family:  Epigenetic
Novelty:  0.00342965
Score:  0.907
Data Source:  STRINGDB
DNMT3A
Tclin
Family:  Epigenetic
Novelty:  0.00085974
Score:  0.871
Data Source:  STRINGDB
IDH1
Tclin
Family:  Enzyme
Novelty:  0.0004831
Score:  0.867
Data Source:  STRINGDB
IDH2
Tclin
Family:  Enzyme
Novelty:  0.00131782
Score:  0.849
Data Source:  STRINGDB
EZH2
Tclin
Family:  Epigenetic
Novelty:  0.00052816
Score:  0.839
Data Source:  STRINGDB
CXXC4
Tbio
Novelty:  0.05876312
Score:  0.823
Data Source:  STRINGDB
WT1
Tbio
Family:  TF
Novelty:  0.00034353
Score:  0.812
Data Source:  STRINGDB
Publication Statistics
PubMed Score  862.76

PubMed score by year
PubTator Score  420.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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