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Tbio
LIN54
Protein lin-54 homolog

Protein Summary
Description
Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context (PubMed:17671431, PubMed:17531812). In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes (PubMed:17671431, PubMed:17531812). In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation (PubMed:17671431, PubMed:17531812). In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner (PubMed:19725879). Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA (PubMed:27465258). LIN54 is a component of the LIN, or DREAM, complex, an essential regulator of cell cycle genes (Schmit et al., 2009 [PubMed 19725879]).[supplied by OMIM, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340417
  • ENSP00000341947
  • ENSG00000189308
  • ENST00000442461
  • ENSP00000398265
  • ENST00000446851
  • ENSP00000407139
  • ENST00000505397
  • ENSP00000425844
  • ENST00000506560
  • ENSP00000423475
  • ENST00000508171
  • ENSP00000427413
  • ENST00000510557
  • ENSP00000421045

Symbol
  • CXCDC1
  • KIAA2037
  • TCX1
  • JC8.6
  • CXCDC1
  • MIP120
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.77
microRNA
0.7
transcription factor binding site profile
0.66
tissue sample
0.65
tissue
0.55


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.54   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.54   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
1
1
78.5
hematocrit
2
2
2
77
hemoglobin measurement
1
1
1
63
red blood cell distribution width
2
1
2
59
lymphocyte percentage of leukocytes
2
2
2
55.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
78.5
hematocrit
2
77
hemoglobin measurement
1
63
red blood cell distribution width
2
59
lymphocyte percentage of leukocytes
2
55.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lin-54 DREAM MuvB core complex component
VGNC:2978
461208
Macaque
lin-54 DREAM MuvB core complex component
693562
Mouse
MGI:2140902
231506
Rat
RGD:1311361
305171
Dog
lin-54 DREAM MuvB core complex component
VGNC:42685
478454
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lin-54 DREAM MuvB core complex component
Macaque
lin-54 DREAM MuvB core complex component
Mouse
Rat
Dog
lin-54 DREAM MuvB core complex component
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q6MZP7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cyclin A:Cdk2-associated events at S phase entry
Reactome
Cyclin E associated events during G1/S transition
Reactome
G0 and Early G1
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cyclin A:Cdk2-associated events at S phase entry
Cyclin E associated events during G1/S transition
G0 and Early G1
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (76)
1 – 10 of 76
LIN37
Tdark
Novelty: 0.27040489
p_int: 0.999999955
p_ni: 4.5e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
LIN9
Tbio
Novelty: 0.01112853
p_int: 0.999998709
p_ni: 0.00000129
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
MYBL1
Tbio
Family: TF
Novelty: 0.00695014
p_int: 0.999994152
p_ni: 0.000005849
Score: 0.918
Data Source: BioPlex,STRINGDB
RPN2
Tbio
Family: Enzyme
Novelty: 0.01796569
p_int: 0.999986811
p_ni: 0.000013189
Score: 0.561
Data Source: BioPlex,STRINGDB
L3MBTL2
Tbio
Family: Epigenetic
Novelty: 0.11193867
p_int: 0.999968901
p_ni: 0.000031099
Score: 0.34
Data Source: BioPlex,STRINGDB
CCDC74A
Tdark
Novelty: 1.52601156
p_int: 0.999957239
p_ni: 0.000042761
Data Source: BioPlex
TUSC3
Tbio
Novelty: 0.01388722
p_int: 0.999447359
p_ni: 0.00055162
p_wrong: 0.000001021
Score: 0.419
Data Source: BioPlex,STRINGDB
IKZF5
Tbio
Family: TF
Novelty: 0.36596327
p_int: 0.999306227
p_ni: 0.0006935
p_wrong: 2.73e-7
Score: 0.189
Data Source: BioPlex,STRINGDB
SPINT2
Tbio
Family: Enzyme
Novelty: 0.0046602
p_int: 0.998816932
p_ni: 0.001182958
p_wrong: 1.11e-7
Data Source: BioPlex
PSMC3
Tbio
Family: Enzyme
Novelty: 0.04026019
p_int: 0.992751546
p_ni: 0.007248437
p_wrong: 1.7e-8
Score: 0.177
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  20.54

PubMed score by year
PubTator Score  5.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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