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Tbio
LIN54
Protein lin-54 homolog

Protein Summary
Description
Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context (PubMed:17671431, PubMed:17531812). In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes (PubMed:17671431, PubMed:17531812). In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation (PubMed:17671431, PubMed:17531812). In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner (PubMed:19725879). Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA (PubMed:27465258). LIN54 is a component of the LIN, or DREAM, complex, an essential regulator of cell cycle genes (Schmit et al., 2009 [PubMed 19725879]).[supplied by OMIM, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340417
  • ENSP00000341947
  • ENSG00000189308
  • ENST00000442461
  • ENSP00000398265
  • ENST00000446851
  • ENSP00000407139
  • ENST00000505397
  • ENSP00000425844
  • ENST00000506560
  • ENSP00000423475
  • ENST00000508171
  • ENSP00000427413
  • ENST00000510557
  • ENSP00000421045

Symbol
  • CXCDC1
  • KIAA2037
  • TCX1
  • JC8.6
  • CXCDC1
  • MIP120
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.77
microRNA
0.7
transcription factor binding site profile
0.66
tissue sample
0.65
tissue
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.86   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.86   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
LIN37
Tdark
Novelty:  0.27040489
p_int:  0.999999955
p_ni:  4.5e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
LIN9
Tbio
Novelty:  0.01112853
p_int:  0.999998709
p_ni:  0.00000129
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
MYBL1
Tbio
Family:  TF
Novelty:  0.00695014
p_int:  0.999994152
p_ni:  0.000005849
Score:  0.918
Data Source:  BioPlex,STRINGDB
RPN2
Tbio
Family:  Enzyme
Novelty:  0.01796569
p_int:  0.999986811
p_ni:  0.000013189
Score:  0.561
Data Source:  BioPlex,STRINGDB
L3MBTL2
Tbio
Family:  Epigenetic
Novelty:  0.11193867
p_int:  0.999968901
p_ni:  0.000031099
Score:  0.34
Data Source:  BioPlex,STRINGDB
CCDC74A
Tdark
Novelty:  1.52601156
p_int:  0.999957239
p_ni:  0.000042761
Data Source:  BioPlex
TUSC3
Tbio
Novelty:  0.01388722
p_int:  0.999447359
p_ni:  0.00055162
p_wrong:  0.000001021
Score:  0.419
Data Source:  BioPlex,STRINGDB
IKZF5
Tbio
Family:  TF
Novelty:  0.36596327
p_int:  0.999306227
p_ni:  0.0006935
p_wrong:  2.73e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
SPINT2
Tbio
Family:  Enzyme
Novelty:  0.0046602
p_int:  0.998816932
p_ni:  0.001182958
p_wrong:  1.11e-7
Data Source:  BioPlex
PSMC3
Tbio
Family:  Enzyme
Novelty:  0.04026019
p_int:  0.992751546
p_ni:  0.007248437
p_wrong:  1.7e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cyclin A:Cdk2-associated events at S phase entry
Reactome
Cyclin E associated events during G1/S transition
Reactome
G0 and Early G1
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cyclin A:Cdk2-associated events at S phase entry
Cyclin E associated events during G1/S transition
G0 and Early G1
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
2
2
2
80.3
hematocrit
2
2
2
78.7
red blood cell density measurement
1
1
1
78.3
lymphocyte count
1
1
1
69.3
erythrocyte count
2
2
2
64.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
2
80.3
hematocrit
2
78.7
red blood cell density measurement
1
78.3
lymphocyte count
1
69.3
erythrocyte count
2
64.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lin-54 DREAM MuvB core complex component
VGNC:2978
461208
Macaque
lin-54 DREAM MuvB core complex component
693562
Mouse
MGI:2140902
231506
Rat
RGD:1311361
305171
Dog
lin-54 DREAM MuvB core complex component
VGNC:42685
478454
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lin-54 DREAM MuvB core complex component
Macaque
lin-54 DREAM MuvB core complex component
Mouse
Rat
Dog
lin-54 DREAM MuvB core complex component
Publication Statistics
PubMed Score 20.86
PubMed score by year
PubTator Score 5.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title