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Tbio
B4GALNT3
Beta-1,4-N-acetylgalactosaminyltransferase 3

Protein Summary
Description
Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. Mediates the N,N'-diacetyllactosediamine formation on gastric mucosa. B4GALNT3 transfers N-acetylgalactosamine (GalNAc) onto glucosyl residues to form N,N-prime-diacetyllactosediamine (LacdiNAc, or LDN), a unique terminal structure of cell surface N-glycans (Ikehara et al., 2006 [PubMed 16728562]).[supplied by OMIM, Aug 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266383
  • ENSP00000266383
  • ENSG00000139044
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.72
virus perturbation
0.59
cellular component
0.57
cell type or tissue
0.56
tissue sample
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.15   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.15   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
3
2
2
23.2
95.6
heel bone mineral density
3
3
4
94.5
monocyte count
2
2
2
87.4
sclerostin measurement
1
1
1
84
monocyte percentage of leukocytes
2
2
2
83.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
23.2
95.6
heel bone mineral density
4
94.5
monocyte count
2
87.4
sclerostin measurement
1
84
monocyte percentage of leukocytes
2
83.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
beta-1,4-N-acetyl-galactosaminyltransferase 3
VGNC:4945
451738
Macaque
beta-1,4-N-acetyl-galactosaminyltransferase 3
706259
Mouse
MGI:3041155
330406
Rat
RGD:1561056
500306
Dog
beta-1,4-N-acetyl-galactosaminyltransferase 3
VGNC:38347
486751
Species
Name
OMA
EggNOG
Inparanoid
Chimp
beta-1,4-N-acetyl-galactosaminyltransferase 3
Macaque
beta-1,4-N-acetyl-galactosaminyltransferase 3
Mouse
Rat
Dog
beta-1,4-N-acetyl-galactosaminyltransferase 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6L9W6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (34)
1 – 10 of 34
PILRA
Tbio
Novelty:  0.05154386
p_int:  0.999636747
p_ni:  0.000363252
Score:  0.52
Data Source:  BioPlex,STRINGDB
SCGB2A2
Tbio
Novelty:  0.01594053
p_int:  0.998053378
p_ni:  0.000366586
p_wrong:  0.001580036
Data Source:  BioPlex
GAA
Tclin
Family:  Enzyme
Novelty:  0.0063246
p_int:  0.997127455
p_ni:  0.002717307
p_wrong:  0.000155237
Score:  0.287
Data Source:  BioPlex,STRINGDB
LRRC55
Tbio
Family:  IC
Novelty:  0.25121277
p_int:  0.823851662
p_ni:  0.010767333
p_wrong:  0.165381004
Data Source:  BioPlex
B4GALNT4
Tdark
Family:  Enzyme
Novelty:  0.19278471
Score:  0.815
Data Source:  STRINGDB
FUT9
Tbio
Family:  Enzyme
Novelty:  0.02880554
Score:  0.62
Data Source:  STRINGDB
CHPF
Tbio
Family:  Enzyme
Novelty:  0.02590604
Score:  0.618
Data Source:  STRINGDB
B4GALNT2
Tbio
Family:  Enzyme
Novelty:  0.00499206
Score:  0.576
Data Source:  STRINGDB
TRARG1
Tbio
Novelty:  0.07729433
Score:  0.552
Data Source:  STRINGDB
GCNT7
Tbio
Family:  Enzyme
Novelty:  0.06366391
Score:  0.545
Data Source:  STRINGDB
Publication Statistics
PubMed Score  6.15

PubMed score by year
PubTator Score  11.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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