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Tbio
PDE12
2',5'-phosphodiesterase 12

Protein Summary
Description
Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311180
  • ENSP00000309142
  • ENSG00000174840

Symbol
  • 2-PDE
  • 2'-PDE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.92
transcription factor perturbation
0.88
transcription factor binding site profile
0.83
microRNA
0.77
cell type or tissue
0.71


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.01   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.01   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 12
VGNC:7094
461027
Macaque
phosphodiesterase 12
703552
Mouse
MGI:2443226
211948
Dog
phosphodiesterase 12
VGNC:44347
484714
Horse
phosphodiesterase 12
VGNC:21238
100058532
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 12
Macaque
phosphodiesterase 12
Mouse
Dog
phosphodiesterase 12
Horse
phosphodiesterase 12
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q6L8Q7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
OAS antiviral response
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
OAS antiviral response
Gene Ontology Terms (20)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (54)
1 – 10 of 54
CNOT1
Tbio
Novelty: 0.00362753
Score: 0.841
Data Source: STRINGDB
CNOT9
Tbio
Novelty: 0.05592835
Score: 0.801
Data Source: STRINGDB
ELAC2
Tbio
Family: Enzyme
Novelty: 0.01234318
Score: 0.772
Data Source: STRINGDB
MTPAP
Tbio
Family: Enzyme
Novelty: 0.03447508
Score: 0.767
Data Source: STRINGDB
PNPT1
Tbio
Family: Enzyme
Novelty: 0.00339969
Score: 0.732
Data Source: STRINGDB
CNOT7
Tchem
Novelty: 0.04551853
Score: 0.727
Data Source: STRINGDB
SLC25A19
Tbio
Family: Transporter
Novelty: 0.00604407
Score: 0.718
Data Source: STRINGDB
DPYD
Tclin
Family: Enzyme
Novelty: 0.00207216
Score: 0.71
Data Source: STRINGDB
CNOT8
Tbio
Novelty: 0.01700084
Score: 0.709
Data Source: STRINGDB
EXO5
Tbio
Family: Enzyme
Novelty: 0.01679942
Score: 0.663
Data Source: STRINGDB
Publication Statistics
PubMed Score  32.01

PubMed score by year
PubTator Score  13.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer