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Tdark
KRTAP5-4
Keratin-associated protein 5-4

Protein Summary
Description
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000630519
  • ENSP00000486225
  • ENSG00000278620

Symbol
  • KAP5.4
  • KRTAP5.4
  • KRTAP5.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.67
cell line
0.48
tissue sample
0.48
tissue
0.38
cellular component
0.31


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.2   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.2   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6L8H1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (83)
1 – 10 of 83
KRTAP5-2
Tdark
Novelty: 3.93025514
Score: 0.824
Data Source: STRINGDB
LCE3B
Tbio
Novelty: 0.05400263
Score: 0.737
Data Source: STRINGDB
KRTAP6-3
Tdark
Novelty: 0.28055117
Score: 0.655
Data Source: STRINGDB
KRTAP22-1
Tdark
Novelty: 0.75498951
Score: 0.641
Data Source: STRINGDB
KRTAP11-1
Tbio
Novelty: 0.20865014
Score: 0.586
Data Source: STRINGDB
KRTAP13-3
Tdark
Novelty: 0.50342897
Score: 0.582
Data Source: STRINGDB
KRTAP24-1
Tdark
Novelty: 0.3470695
Score: 0.579
Data Source: STRINGDB
KRTAP6-2
Tdark
Novelty: 1.37501842
Score: 0.56
Data Source: STRINGDB
KRTAP26-1
Tdark
Novelty: 0.48053029
Score: 0.557
Data Source: STRINGDB
KRTAP3-2
Tdark
Novelty: 1.99836821
Score: 0.556
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.20

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer