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Tbio
NIPBL
Nipped-B-like protein

Protein Summary
Description
Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitement to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitement to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282516
  • ENSP00000282516
  • ENSG00000164190
  • ENST00000448238
  • ENSP00000406266

Symbol
  • IDN3
  • SCC2
  • CDLS
  • IDN3
  • Scc2
  • CDLS1
  • IDN3-B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
virus perturbation
0.98
biological process
0.96
transcription factor perturbation
0.94
interacting protein
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 243.16   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 243.16   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
1
1
81.9
body height
2
2
2
71.7
diet measurement
1
1
1
0
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
81.9
body height
2
71.7
diet measurement
1
0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NIPBL, cohesin loading factor
VGNC:10103
461917
Macaque
NIPBL, cohesin loading factor
701209
Mouse
MGI:1913976
71175
Rat
RGD:1306393
294787
Dog
NIPBL, cohesin loading factor
VGNC:43819
489226
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NIPBL, cohesin loading factor
Macaque
NIPBL, cohesin loading factor
Mouse
Rat
Dog
NIPBL, cohesin loading factor
Protein Structure (0 Structures, 9 AlphaFold Models)
RepresentationColor Scheme

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cohesin Loading onto Chromatin
Reactome
M Phase
Reactome
Mitotic Telophase/Cytokinesis
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cohesin Loading onto Chromatin
M Phase
Mitotic Telophase/Cytokinesis
Gene Ontology Terms (58)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (174)
1 – 10 of 174
GPSM3
Tbio
Novelty: 0.01632501
p_int: 0.999895764
p_ni: 0.000003802
p_wrong: 0.000100434
Data Source: BioPlex
NMB
Tbio
Novelty: 0.00729571
p_int: 0.999894293
p_ni: 0.000055671
p_wrong: 0.000050036
Data Source: BioPlex
ARFGAP1
Tbio
Family: Enzyme
Novelty: 0.02654081
p_int: 0.999842431
p_ni: 0.000028401
p_wrong: 0.000129168
Score: 0.324
Data Source: BioPlex,STRINGDB
ATXN7L1
Tdark
Novelty: 0.43694835
p_int: 0.830682543
p_ni: 0.00192658
p_wrong: 0.167390877
Data Source: BioPlex
SMC3
Tbio
Novelty: 0.00474377
Score: 0.999
Data Source: STRINGDB
MAU2
Tdark
Novelty: 0.00594861
Score: 0.998
Data Source: Reactome,STRINGDB
SMC1A
Tbio
Novelty: 0.00898427
Score: 0.997
Data Source: STRINGDB
RAD21
Tbio
Novelty: 0.00270936
Score: 0.996
Data Source: STRINGDB
PDS5A
Tbio
Novelty: 0.0142948
Score: 0.996
Data Source: Reactome,STRINGDB
PDS5B
Tbio
Novelty: 0.00295057
Score: 0.994
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  243.16

PubMed score by year
PubTator Score  138.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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