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Tdark
LCN12
Epididymal-specific lipocalin-12

Protein Classes
Protein Summary
Description
Binds all-trans retinoic acid and may act as a retinoid carrier protein within the epididymis. May play a role in male fertility (By similarity). Members of the lipocalin family, such as LCN12, have a common structure consisting of an 8-stranded antiparallel beta-barrel that forms a cup-shaped ligand-binding pocket or calyx. Lipocalins generally bind small hydrophobic ligands and transport them to specific cells (Suzuki et al., 2004 [PubMed 15363845]).[supplied by OMIM, Aug 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371633
  • ENSP00000360696
  • ENSG00000184925
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.72
protein domain
0.58
interacting protein
0.57
cell line
0.53
tissue sample
0.5


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.83   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.83   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
3
4
91.5
monocyte percentage of leukocytes
2
2
2
88
leukocyte count
2
2
3
70.2
central corneal thickness
3
2
0
2.9
69.8
lymphocyte percentage of leukocytes
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
4
91.5
monocyte percentage of leukocytes
2
88
leukocyte count
3
70.2
central corneal thickness
0
2.9
69.8
lymphocyte percentage of leukocytes
1
49.5
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lipocalin 12
VGNC:13906
746933
Macaque
lipocalin 12
708099
Mouse
MGI:1924951
77701
Rat
RGD:1589474
680602
Dog
lipocalin 12 [Source:HGNC Symbol;Acc:HGNC:28733]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lipocalin 12
Macaque
lipocalin 12
Mouse
Rat
Dog
lipocalin 12 [Source:HGNC Symbol;Acc:HGNC:28733]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6JVE5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of fatty acids
Reactome
Transport of small molecules
Reactome
Transport of vitamins, nucleosides, and related molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Transport of fatty acids
Transport of small molecules
Transport of vitamins, nucleosides, and related molecules
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (41)
1 – 10 of 41
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.961735114
p_ni:  0.038264886
Data Source:  BioPlex
ZNF469
Tbio
Family:  TF
Novelty:  0.03776751
Score:  0.631
Data Source:  STRINGDB
TMEM248
Tdark
Novelty:  2.69323589
Score:  0.63
Data Source:  STRINGDB
LCN9
Tdark
Novelty:  0.25490072
Score:  0.615
Data Source:  STRINGDB
LCN10
Tdark
Novelty:  1.32107702
Score:  0.603
Data Source:  STRINGDB
OBP2A
Tbio
Novelty:  0.02757821
Score:  0.598
Data Source:  STRINGDB
OBP2B
Tdark
Novelty:  0.43500456
Score:  0.58
Data Source:  STRINGDB
RHBDD3
Tbio
Novelty:  0.04564748
Score:  0.559
Data Source:  STRINGDB
LCNL1
Tdark
Novelty:  7.94657763
Score:  0.558
Data Source:  STRINGDB
VKORC1L1
Tbio
Family:  Enzyme
Novelty:  0.11471737
Score:  0.558
Data Source:  STRINGDB
Publication Statistics
PubMed Score  2.83

PubMed score by year
PubTator Score  0.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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