STYK1
Tyrosine-protein kinase STYK1
Protein Summary
Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity). Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008]
- ENST00000075503
- ENSP00000075503
- ENSG00000060140
- NOK
- NOK
- SuRTK106
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.97 | ||
molecular function | 0.94 | ||
trait | 0.75 | ||
cell type or tissue | 0.63 | ||
histone modification site profile | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 51.27 (req: < 5)
Gene RIFs: 23 (req: <= 3)
Antibodies: 297 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 51.27 (req: >= 5)
Gene RIFs: 23 (req: > 3)
Antibodies: 297 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (33)
Nearest Tclin Targets
Pathways (48)
WikiPathways (48)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
WikiPathways | Focal Adhesion | ||||
WikiPathways | Focal Adhesion | ||||
WikiPathways | Focal Adhesion | ||||
WikiPathways | Focal Adhesion | ||||
WikiPathways | AGE/RAGE pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Focal Adhesion | ||||
Focal Adhesion | ||||
Focal Adhesion | ||||
Focal Adhesion | ||||
AGE/RAGE pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (6)
Functions (2)
Components (3)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 1 | 6.5 | ||||||
1 | 1 | 1 | 4.1 | ||||||
dentures | 2 | 1 | 2 | 4.1 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
1 | 6.5 | ||||||
1 | 4.1 | ||||||
dentures | 2 | 4.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | serine/threonine/tyrosine kinase 1 | VGNC:13455 | 473363 | |||||
Macaque | serine/threonine/tyrosine kinase 1 | 717844 | ||||||
Mouse | MGI:2141396 | 243659 | ||||||
Rat | RGD:1564211 | 500340 | ||||||
Horse | serine/threonine/tyrosine kinase 1 | VGNC:23739 | 100063237 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | serine/threonine/tyrosine kinase 1 | |||||
Macaque | serine/threonine/tyrosine kinase 1 | |||||
Mouse | ||||||
Rat | ||||||
Horse | serine/threonine/tyrosine kinase 1 | |||||
Publication Statistics
PubMed Score 51.27
PubMed score by year
PubTator Score 140.71
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (32)
GeneRif Annotations (23)
Items per page:
0 of 0
PMID | Year | Title |
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