You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
STYK1
Tyrosine-protein kinase STYK1

Protein Summary
Description
Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity). Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000075503
  • ENSP00000075503
  • ENSG00000060140

Symbol
  • NOK
  • NOK
  • SuRTK106
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.97
molecular function
0.94
trait
0.75
cell type or tissue
0.63
histone modification site profile
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.27   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 297   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.27   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 297   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
HSP90AA5P
Tdark
p_int:  0.99984875
p_ni:  0.00015125
Data Source:  BioPlex
HSP90AB4P
Tdark
p_int:  0.998905743
p_ni:  0.001094257
Data Source:  BioPlex
HIF1AN
Tbio
Novelty:  0.00861018
p_int:  0.995231918
p_ni:  0.004768082
Data Source:  BioPlex
CDC37
Tbio
Novelty:  0.03730196
p_int:  0.760428438
p_ni:  0.239571562
Data Source:  BioPlex
MPP6
Tbio
Novelty:  0.08883057
Score:  0.718
Data Source:  STRINGDB
FASLG
Tbio
Novelty:  0.0003303
Score:  0.668
Data Source:  STRINGDB
SBK1
Tchem
Family:  Kinase
Novelty:  0.05227715
Score:  0.647
Data Source:  STRINGDB
GABARAPL1
Tbio
Novelty:  0.00212657
Score:  0.622
Data Source:  STRINGDB
MPP5
Tbio
Novelty:  0.01707773
Score:  0.58
Data Source:  STRINGDB
KLRD1
Tbio
Novelty:  0.00218019
Score:  0.573
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (48)
Find Similar Targets
Items per page:
1 – 5 of 48
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Focal Adhesion
WikiPathways
Focal Adhesion
WikiPathways
Focal Adhesion
WikiPathways
Focal Adhesion
WikiPathways
AGE/RAGE pathway
Name
Explore in Pharos
Explore in Source
Focal Adhesion
Focal Adhesion
Focal Adhesion
Focal Adhesion
AGE/RAGE pathway
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
6.5
1
1
1
4.1
dentures
2
1
2
4.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
6.5
1
4.1
dentures
2
4.1
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine/threonine/tyrosine kinase 1
VGNC:13455
473363
Macaque
serine/threonine/tyrosine kinase 1
717844
Mouse
MGI:2141396
243659
Rat
RGD:1564211
500340
Horse
serine/threonine/tyrosine kinase 1
VGNC:23739
100063237
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine/threonine/tyrosine kinase 1
Macaque
serine/threonine/tyrosine kinase 1
Mouse
Rat
Horse
serine/threonine/tyrosine kinase 1
Publication Statistics
PubMed Score 51.27
PubMed score by year
PubTator Score 140.71
PubTator score by year
Patents
Patents by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title