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Tbio
STYK1
Tyrosine-protein kinase STYK1

Protein Summary
Description
Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity). Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000075503
  • ENSP00000075503
  • ENSG00000060140

Symbol
  • NOK
  • NOK
  • SuRTK106
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.97
molecular function
0.94
trait
0.75
cell type or tissue
0.63
histone modification site profile
0.6


IDG Partner Tools
GlyGen
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.62   (req: < 5)
View Publications
Gene RIFs: 23   (req: <= 3)
View Gene RIFs
Antibodies: 297   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.62   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 297   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (48)
Items per page:
1 – 5 of 48
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Focal Adhesion
543 targets
WP306_r105598
WikiPathways
Focal Adhesion
543 targets
WP306_r105598
WikiPathways
Focal Adhesion
543 targets
WP306_r105598
WikiPathways
Focal Adhesion
543 targets
WP306_r105598
WikiPathways
AGE/RAGE pathway
391 targets
WP2324_r105867
Name
Explore in Pharos
Explore in Source
Focal Adhesion
543 targets
WP306_r105598
Focal Adhesion
543 targets
WP306_r105598
Focal Adhesion
543 targets
WP306_r105598
Focal Adhesion
543 targets
WP306_r105598
AGE/RAGE pathway
391 targets
WP2324_r105867
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
non-membrane spanning protein tyrosine kinase activity
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
ATP binding
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (33)
1 – 10 of 33
HSP90AA5P
Tdark
p_int: 0.99984875
p_ni: 0.00015125
Data Source: BioPlex
HSP90AB4P
Tdark
p_int: 0.998905743
p_ni: 0.001094257
Data Source: BioPlex
HIF1AN
Tbio
Novelty: 0.00861018
p_int: 0.995231918
p_ni: 0.004768082
Data Source: BioPlex
CDC37
Tbio
Novelty: 0.03730196
p_int: 0.760428438
p_ni: 0.239571562
Data Source: BioPlex
MPP6
Tbio
Novelty: 0.08883057
Score: 0.718
Data Source: STRINGDB
FASLG
Tbio
Novelty: 0.0003303
Score: 0.668
Data Source: STRINGDB
SBK1
Tchem
Family: Kinase
Novelty: 0.05227715
Score: 0.647
Data Source: STRINGDB
GABARAPL1
Tbio
Novelty: 0.00212657
Score: 0.622
Data Source: STRINGDB
MPP5
Tbio
Novelty: 0.01707773
Score: 0.58
Data Source: STRINGDB
KLRD1
Tbio
Novelty: 0.00218019
Score: 0.573
Data Source: STRINGDB
Publication Statistics
PubMed Score  49.62

PubMed score by year
PubTator Score  140.71

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer