Protein Summary
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. May play a role in cell-cell interactions. This prostate-specific gene encodes a cytoplasmic protein, as well as a polytopic membrane protein which may serve as a target in prostate cancer diagnosis and immunotherapy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2011]
- ENST00000274979
- ENSP00000274979
- ENSG00000146205
- ENST00000402430
- ENSP00000385418
- ENST00000402530
- ENSP00000383985
- NGEP
- PCANAP5
- TMEM16G
- NGEP
- DTMPP
- IPCA5
- D-TMPP
- IPCA-5
- PCANAP5
- TMEM16G
- PCANAP5L
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.73 | ||
tissue sample | 0.68 | ||
cell line | 0.67 | ||
cellular component | 0.67 | ||
cell type or tissue | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.56 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 107 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.56 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 107 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (28)
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Ion channel transport | ||||
Reactome | Stimuli-sensing channels | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Ion channel transport | ||||
Stimuli-sensing channels | ||||
Transport of small molecules | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (3)
Components (5)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (19)
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body height | 2 | 2 | 2 | 87.5 | |||||
alkaline phosphatase measurement | 2 | 2 | 1 | 6.3 | 77 | ||||
mean corpuscular volume | 1 | 1 | 1 | 72.9 | |||||
fibrinogen measurement | 2 | 1 | 2 | 70.9 | |||||
balding measurement | 1 | 1 | 1 | 67.8 | |||||
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body height | 2 | 87.5 | |||||
alkaline phosphatase measurement | 1 | 6.3 | 77 | ||||
mean corpuscular volume | 1 | 72.9 | |||||
fibrinogen measurement | 2 | 70.9 | |||||
balding measurement | 1 | 67.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | anoctamin 7 | VGNC:72 | 743987 | |||||
Macaque | anoctamin 7 | 700819 | ||||||
Mouse | MGI:3052714 | 404545 | ||||||
Rat | RGD:1302987 | 367318 | ||||||
Dog | anoctamin 7 | 486204 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | anoctamin 7 | |||||
Macaque | anoctamin 7 | |||||
Mouse | ||||||
Rat | ||||||
Dog | anoctamin 7 | |||||
Publication Statistics
PubMed Score 19.56
PubMed score by year
PubTator Score 12.34
PubTator score by year
Related Publications
Text Mined References (17)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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