Tbio ANO7 Anoctamin-7

Protein Summary

Description

Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. May play a role in cell-cell interactions. This prostate-specific gene encodes a cytoplasmic protein, as well as a polytopic membrane protein which may serve as a target in prostate cancer diagnosis and immunotherapy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q6IWH7
• Q6IWH6

Gene Name

• ANO7

Ensembl ID

• ENST00000274979
• ENSP00000274979
• ENSG00000146205
• ENST00000402430
• ENSP00000385418
• ENST00000402530
• ENSP00000383985

Symbol

• NGEP
• PCANAP5
• TMEM16G
• NGEP
• DTMPP
• IPCA5
• D-TMPP
• IPCA-5
• PCANAP5
• TMEM16G
• PCANAP5L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.73
tissue sample	0.68
cell line	0.67
cellular component	0.67
cell type or tissue	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.07   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 107   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.07   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0