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Tbio
PTCRA
Pre T-cell antigen receptor alpha

Protein Summary
Description
The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development. The protein encoded by this gene is a single-pass type I membrane protein that is found in immmature but not mature T-cells. Along with TCRB and CD3 complex, the encoded protein forms the pre-T-cell receptor complex, which regulates early T-cell development. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304672
  • ENSP00000304447
  • ENSG00000171611
  • ENST00000441198
  • ENSP00000409550
  • ENST00000446507
  • ENSP00000392288

Symbol
  • PTA
  • PT-ALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.69
cell line
0.54
gene perturbation
0.52
small molecule perturbation
0.52
disease perturbation
0.49


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.38   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.38   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
2
3
3
92.7
apolipoprotein B measurement
2
3
3
86.8
high density lipoprotein cholesterol measurement
3
3
4
83.6
bilirubin measurement
1
1
1
67.3
homocysteine measurement
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
3
92.7
apolipoprotein B measurement
3
86.8
high density lipoprotein cholesterol measurement
4
83.6
bilirubin measurement
1
67.3
homocysteine measurement
1
47.7
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pre T cell antigen receptor alpha
VGNC:3677
462701
Macaque
pre T-cell antigen receptor alpha
697470
Rat
RGD:621388
116462
Dog
pre T cell antigen receptor alpha
VGNC:54346
481804
Horse
pre T-cell antigen receptor alpha
100067052
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pre T cell antigen receptor alpha
Macaque
pre T-cell antigen receptor alpha
Rat
Dog
pre T cell antigen receptor alpha
Horse
pre T-cell antigen receptor alpha
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q6ISU1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
NOTCH3 Intracellular Domain Regulates Transcription (R-HSA-9013508)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
NOTCH3 Intracellular Domain Regulates Transcription
Reactome
Signal Transduction
Reactome
Signaling by NOTCH
Reactome
Signaling by NOTCH3
Name
Explore in Pharos
Explore in Source
NOTCH3 Intracellular Domain Regulates Transcription
Signal Transduction
Signaling by NOTCH
Signaling by NOTCH3
Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (56)
1 – 10 of 56
TCEA1
Tbio
Novelty:  0.00547888
p_int:  0.978438939
p_ni:  0.021560972
p_wrong:  8.9e-8
Score:  0.219
Data Source:  BioPlex,STRINGDB
CTH
Tchem
Family:  Enzyme
Novelty:  0.0017155
p_int:  0.880320188
p_ni:  0.119638144
p_wrong:  0.000041668
Score:  0.239
Data Source:  BioPlex,STRINGDB
FEN1
Tchem
Family:  Enzyme
Novelty:  0.00082515
p_int:  0.858701917
p_ni:  0.141298082
Score:  0.309
Data Source:  BioPlex,STRINGDB
NOTCH3
Tchem
Novelty:  0.000953
Score:  0.962
Data Source:  STRINGDB
RBPJ
Tchem
Family:  TF
Novelty:  0.00168834
Score:  0.923
Data Source:  STRINGDB
MAML1
Tbio
Novelty:  0.01302751
Score:  0.913
Data Source:  STRINGDB
MAMLD1
Tbio
Novelty:  0.01681081
Score:  0.904
Data Source:  STRINGDB
MAML2
Tbio
Novelty:  0.00836375
Score:  0.902
Data Source:  STRINGDB
MAML3
Tbio
Novelty:  0.05574812
Score:  0.9
Data Source:  STRINGDB
HID1
Tdark
Novelty:  0.68399313
Score:  0.716
Data Source:  STRINGDB
Publication Statistics
PubMed Score  85.38

PubMed score by year
PubTator Score  117.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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