LAIR2
Leukocyte-associated immunoglobulin-like receptor 2
Protein Summary
The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to leukocyte-associated immunoglobulin-like receptor 1, a membrane-bound receptor that modulates innate immune response. The protein encoded by this locus is a soluble receptor that may play roles in both inhibition of collagen-induced platelet aggregation and vessel formation during placental implantation. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]
- ENST00000301202
- ENSP00000301202
- ENSG00000167618
- ENST00000351841
- ENSP00000301203
- ENST00000612901
- ENSP00000478193
- ENSG00000274084
- ENST00000620256
- ENSP00000477747
- ENST00000621280
- ENSP00000480904
- ENSG00000277335
- ENST00000622556
- ENSP00000477535
- CD306
- CD306
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell line | 0.52 | ||
cell type or tissue | 0.52 | ||
tissue | 0.46 | ||
small molecule perturbation | 0.43 | ||
chemical | 0.41 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 17.86 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 196 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 17.86 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 196 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (42)
COL4A6
Novelty: 0.02524039
p_int: 0.999997546
p_ni: 0.000002092
p_wrong: 3.62e-7
Data Source: BioPlex
COL4A1
Novelty: 0.00358049
p_int: 0.999992999
p_ni: 0.000004838
p_wrong: 0.000002163
Data Source: BioPlex
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Immune System | ||||
Reactome | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Immune System | ||||
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||||
Viral Interactions (0)
Gene Ontology Terms (2)
Components (1)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations (null)
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
self reported educational attainment | 1 | 1 | 1 | 45.7 | |||||
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 34.9 | |||||
apolipoprotein A 1 measurement | 1 | 1 | 1 | 32.9 | |||||
1 | 1 | 0 | 1.5 | 31.4 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
self reported educational attainment | 1 | 45.7 | |||||
high density lipoprotein cholesterol measurement | 1 | 34.9 | |||||
apolipoprotein A 1 measurement | 1 | 32.9 | |||||
0 | 1.5 | 31.4 | |||||
Find similar targets by:
IDG Resources
Orthologs
Publication Statistics
PubMed Score 17.86
PubMed score by year
PubTator Score 15.62
PubTator score by year
Related Publications
Text Mined References (18)
GeneRif Annotations (9)
Items per page:
0 of 0
PMID | Year | Title |
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