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Tdark
EIF5AL1
Eukaryotic translation initiation factor 5A-1-like

Protein Summary
Description
mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000520547
  • ENSP00000430706
  • ENSG00000253626

Symbol
  • EIF5A
  • eIF-4D
  • eIF-5A
  • EIF5AP1
  • eIF-5A1
  • eIF-5A-1
  • bA342M3.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
cell type or tissue
0.61
microRNA
0.55
tissue
0.53
cell line
0.52


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.55   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 59   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.55   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6IS14-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (166)
1 – 10 of 166
EEF1G
Tbio
Novelty:  0.01473013
Score:  0.91
Data Source:  STRINGDB
RPL9
Tbio
Novelty:  0.00845583
Score:  0.891
Data Source:  STRINGDB
RPL11
Tbio
Novelty:  0.00448962
Score:  0.885
Data Source:  STRINGDB
RAN
Tchem
Family:  Enzyme
Novelty:  0.00160888
Score:  0.885
Data Source:  STRINGDB
RPL5
Tbio
Novelty:  0.00663792
Score:  0.881
Data Source:  STRINGDB
RPL38
Tbio
Novelty:  0.02694553
Score:  0.88
Data Source:  STRINGDB
RPL15
Tbio
Novelty:  0.02466708
Score:  0.875
Data Source:  STRINGDB
DHPS
Tchem
Family:  Enzyme
Novelty:  0.00776893
Score:  0.864
Data Source:  STRINGDB
RPS18
Tbio
Novelty:  0.00688684
Score:  0.85
Data Source:  STRINGDB
RPS15
Tbio
Novelty:  0.00635155
Score:  0.843
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1.55

PubMed score by year
PubTator Score  0.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer