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Tbio
SDE2
Replication stress response regulator SDE2

Protein Summary
Description
Involved in both DNA replication and cell cycle control (PubMed:27906959). Unprocessed SDE2 interacts with PCNA via its PIP-box. The interaction with PCNA prevents monoubiquitination of the latter thereby inhibiting translesion DNA synthesis. The binding of SDE2 to PCNA also leads to processing of SDE2 by an unidentified deubiquitinating enzyme, cleaving off the N-terminal ubiquitin-like domain. The resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner (PubMed:27906959). Binding of SDE2 to PCNA is necessary to counteract damage due to ultraviolet light induced replication stress. The complete degradation of SDE2 is necessary to allow S-phase progression (PubMed:27906959).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272091
  • ENSP00000272091
  • ENSG00000143751

Symbol
  • C1orf55
  • C1orf55
  • dJ671D7.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
virus perturbation
0.76
cellular component
0.75
tissue sample
0.73
drug perturbation
0.71


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.89   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.89   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SDE2 telomere maintenance homolog
VGNC:9899
457781
Mouse
MGI:2384788
208768
Rat
RGD:1305572
289315
Dog
SDE2 telomere maintenance homolog
VGNC:45946
480111
Horse
SDE2 telomere maintenance homolog
VGNC:22767
100054411
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SDE2 telomere maintenance homolog
Mouse
Rat
Dog
SDE2 telomere maintenance homolog
Horse
SDE2 telomere maintenance homolog
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (37)
1 – 10 of 37
PRPF19
Tbio
Novelty: 0.01616737
Score: 0.749
Data Source: STRINGDB
SLC2A13
Tbio
Family: Transporter
Novelty: 0.04641021
Score: 0.731
Data Source: STRINGDB
GNL3L
Tbio
Novelty: 0.16432364
Score: 0.666
Data Source: STRINGDB
RFC3
Tbio
Novelty: 0.02712951
Score: 0.64
Data Source: STRINGDB
OR1M1
Tdark
Family: oGPCR
Novelty: 3.43302991
Score: 0.63
Data Source: STRINGDB
DNHD1
Tdark
Novelty: 0.96803718
Score: 0.605
Data Source: STRINGDB
DCLRE1A
Tbio
Novelty: 0.0104321
Score: 0.571
Data Source: STRINGDB
CCT4
Tbio
Novelty: 0.01176123
Score: 0.542
Data Source: STRINGDB
MLH3
Tbio
Novelty: 0.01295793
Score: 0.53
Data Source: STRINGDB
SP4
Tbio
Family: TF
Novelty: 0.02444442
Score: 0.527
Data Source: STRINGDB
Publication Statistics
PubMed Score  23.89

PubMed score by year
PubTator Score  5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer