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Tbio
RAB12
Ras-related protein Rab-12

Protein Summary
Description
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329286
  • ENSP00000331748
  • ENSG00000206418
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
biological process
0.81
transcription factor perturbation
0.8
transcription factor binding site profile
0.74
tissue sample
0.67


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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.27   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.27   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB12, member RAS oncogene family
VGNC:9917
736838
Mouse
MGI:894284
19328
Rat
RGD:3527
25530
Dog
RAB12, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:31332]
Horse
RAB12, member RAS oncogene family
VGNC:22087
100049860
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB12, member RAS oncogene family
Mouse
Rat
Dog
RAB12, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:31332]
Horse
RAB12, member RAS oncogene family
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q6IQ22-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
RAB geranylgeranylation
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
Metabolism of proteins
Post-translational protein modification
RAB GEFs exchange GTP for GDP on RABs
RAB geranylgeranylation
Gene Ontology Terms (20)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (121)
1 – 10 of 121
GDI1
Tbio
Novelty: 0.01710945
p_int: 0.999999989
p_ni: 3e-9
p_wrong: 8e-9
Score: 0.969
Data Source: BioPlex,Reactome,STRINGDB
LRRTM1
Tbio
Novelty: 0.0409182
p_int: 0.994514259
p_ni: 0.000584359
p_wrong: 0.004901382
Score: 0.259
Data Source: BioPlex,STRINGDB
DENND3
Tbio
Novelty: 0.16702884
Score: 0.968
Data Source: Reactome,STRINGDB
GDI2
Tbio
Novelty: 0.02861013
Score: 0.967
Data Source: Reactome,STRINGDB
CHM
Tbio
Family: Enzyme
Novelty: 0.00226278
Score: 0.963
Data Source: Reactome,STRINGDB
CHML
Tbio
Family: Enzyme
Novelty: 0.00509709
Score: 0.959
Data Source: Reactome,STRINGDB
RAB33A
Tbio
Family: Enzyme
Novelty: 0.11617001
Score: 0.949
Data Source: STRINGDB
RAB33B
Tbio
Family: Enzyme
Novelty: 0.06381712
Score: 0.946
Data Source: STRINGDB
RAB1A
Tbio
Family: Enzyme
Novelty: 0.00307527
Score: 0.946
Data Source: STRINGDB
RAB43
Tbio
Family: Enzyme
Novelty: 0.07527576
Score: 0.945
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.27

PubMed score by year
PubTator Score  8.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer