Tdark ZNF770 Zinc finger protein 770

Protein Summary

Description

May be involved in transcriptional regulation.

Uniprot Accession IDs

• Q6IQ21
• Q6ZMZ6
• Q9NWV2

Gene Name

• ZNF770

Ensembl ID

• ENST00000356321
• ENSP00000348673
• ENSG00000198146

Symbol

• PRO1914

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.72
histone modification site profile	0.71
small molecule perturbation	0.64
transcription factor binding site profile	0.63
transcription factor perturbation	0.61

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.23   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 17   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.23   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 17   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	2	1	2		46.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	2		46.4

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Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 770	VGNC:13464	735642
Mouse	zinc finger protein 770	MGI:2445100	228491
Rat	zinc finger protein 770	RGD:1597283	691610
Dog	zinc finger protein 770	VGNC:48812	100687020
Horse	zinc finger protein 770	VGNC:25385	100071735

Species	Name	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 770
Mouse	zinc finger protein 770
Rat	zinc finger protein 770
Dog	zinc finger protein 770
Horse	zinc finger protein 770

Pathways (3)

Reactome (3)

Gene expression (Transcription) (R-HSA-74160)

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1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Gene Ontology Terms (4)

Functions (3)

Components (1)

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10

1 – 3 of 3

GO Term	Evidence	Assigned by
DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (36)

Explore Interacting Targets

1 – 10 of 36

• See Interactions on String-DB

ZNF2

Tbio

Family: TF

Novelty: 0.01062543

p_int: 0.978378577

p_ni: 0.021621419

p_wrong: 4e-9

Data Source: BioPlex

PPAN

Tbio

Novelty: 0.01063709

p_int: 0.915005067

p_ni: 0.08434221

p_wrong: 0.000652723

Data Source: BioPlex

RPL11

Tbio

Novelty: 0.00448962

p_int: 0.896969501

p_ni: 0.103030494

p_wrong: 5e-9

Data Source: BioPlex

CACNG5

Tdark

Family: IC

Novelty: 0.52705448

p_int: 0.883316378

p_ni: 0.116675548

p_wrong: 0.000008074

Data Source: BioPlex

FGF17

Tbio

Novelty: 0.01432991

p_int: 0.87067669

p_ni: 0.129323032

p_wrong: 2.78e-7

Data Source: BioPlex

RPL7A

Tbio

Novelty: 0.01674027

p_int: 0.86232384

p_ni: 0.137675882

p_wrong: 2.78e-7

Data Source: BioPlex

WDR46

Tbio

Novelty: 0.19307408

p_int: 0.828057812

p_ni: 0.171941917

p_wrong: 2.71e-7

Data Source: BioPlex

NIFK

Tbio

Novelty: 0.01221562

p_int: 0.824518675

p_ni: 0.175284953

p_wrong: 0.000196372

Score: 0.232

Data Source: BioPlex,STRINGDB

E4F1

Tbio

Family: TF

Novelty: 0.02192338

p_int: 0.818938418

p_ni: 0.181061553

p_wrong: 2.9e-8

Data Source: BioPlex

H2AFY2

Tbio

Novelty: 0.09948698

p_int: 0.762660208

p_ni: 0.237339781

p_wrong: 1.1e-8

Score: 0.159

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  1.23

PubMed score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Complete proteome
DNA-binding
Isopeptide bond
Metal-binding
Nucleus
Reference proteome
Repeat
Transcription
Transcription regulation
Ubl conjugation

GWAS Trait Find Similar Targets

sex hormone-binding globulin measurement