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Tbio
NAPEPLD
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D

Protein Summary
Description
Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid (PubMed:25684574, PubMed:14634025, PubMed:16527816). Responsible for the generation of these bioactive fatty acid ethanolamides (FAEs), including anandamide (N-arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors (PubMed:14634025). As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose (By similarity). NAPEPLD is a phospholipase D type enzyme that catalyzes the release of N-acylethanolamine (NAE) from N-acyl-phosphatidylethanolamine (NAPE) in the second step of the biosynthesis of N-acylethanolamine (Okamoto et al., 2004 [PubMed 14634025]).[supplied by OMIM, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341533
  • ENSP00000340093
  • ENSG00000161048
  • ENST00000417955
  • ENSP00000407112
  • ENST00000422589
  • ENSP00000412376
  • ENST00000427257
  • ENSP00000392775
  • ENST00000465647
  • ENSP00000419188
  • ENST00000611100
  • ENSP00000482162
  • ENSG00000275723
  • ENST00000622712
  • ENSP00000481285
  • ENST00000632159
  • ENSP00000488504
  • ENST00000632703
  • ENSP00000488648
  • ENST00000633783
  • ENSP00000487770

Symbol
  • C7orf18
  • FMP30
  • C7orf18
  • NAPE-PLD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
histone modification site profile
0.78
metabolite
0.78
microRNA
0.74
kinase perturbation
0.66


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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 135.7   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 135.7   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N-acyl phosphatidylethanolamine phospholipase D
VGNC:14052
472476
Macaque
N-acyl phosphatidylethanolamine phospholipase D
695318
Mouse
MGI:2140885
242864
Rat
RGD:735197
296757
Dog
N-acyl phosphatidylethanolamine phospholipase D
VGNC:43621
100685330
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N-acyl phosphatidylethanolamine phospholipase D
Macaque
N-acyl phosphatidylethanolamine phospholipase D
Mouse
Rat
Dog
N-acyl phosphatidylethanolamine phospholipase D
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (81)
Biosynthesis of A2E, implicated in retinal degradation (R-HSA-2466712)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biosynthesis of A2E, implicated in retinal degradation
Reactome
Disease
Reactome
Diseases associated with visual transduction
Reactome
Diseases of signal transduction
Reactome
G alpha (i) signalling events
Name
Explore in Pharos
Explore in Source
Biosynthesis of A2E, implicated in retinal degradation
Disease
Diseases associated with visual transduction
Diseases of signal transduction
G alpha (i) signalling events
Gene Ontology Terms (25)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (40)
1 – 10 of 40
FAAH
Tchem
Family: Enzyme
Novelty: 0.00162361
Score: 0.956
Data Source: STRINGDB
CNR1
Tclin
Family: GPCR
Novelty: 0.00060063
Score: 0.894
Data Source: STRINGDB
MGLL
Tchem
Family: Enzyme
Novelty: 0.00196912
Score: 0.887
Data Source: STRINGDB
PLD2
Tchem
Family: Enzyme
Novelty: 0.00331129
Score: 0.883
Data Source: STRINGDB
GDE1
Tbio
Family: Enzyme
Novelty: 0.05854843
Score: 0.854
Data Source: STRINGDB
ABHD6
Tchem
Family: Enzyme
Novelty: 0.019314
Score: 0.834
Data Source: STRINGDB
CNR2
Tchem
Family: GPCR
Novelty: 0.00215391
Score: 0.829
Data Source: STRINGDB
ABHD4
Tbio
Family: Enzyme
Novelty: 0.1068785
Score: 0.82
Data Source: STRINGDB
DAGLA
Tchem
Family: Enzyme
Novelty: 0.00959313
Score: 0.811
Data Source: STRINGDB
ARMC10
Tbio
Novelty: 0.08714295
Score: 0.776
Data Source: STRINGDB
Publication Statistics
PubMed Score  135.70

PubMed score by year
PubTator Score  43.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer