Tdark TBC1D3C TBC1 domain family member 3C

Protein Summary

Description

Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). This gene represents one of a cluster of related genes found on chromosome 17. The proteins encoded by this gene family contain a TBC (Tre-2, Bub2p, and Cdc16p) domain and may be involved in GTPase signaling and vesicle trafficking. [provided by RefSeq, Apr 2014]

Uniprot Accession IDs

• Q6IPX1

Gene Name

• TBC1D3C

Ensembl ID

• ENST00000622206
• ENSP00000482345
• ENSG00000278299

Symbol

• TBC1D3D
• PRC17
• TBC1D3
• TBC1D3A
• TBC1D3D

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

PANTHER Classes

Protein / Hydrolase / Tbc1 Domain Family Member 3c

Protein / Enzyme Modulator / G-protein Modulator / Tbc1 Domain Family Member 3c

Protein / ... / Cysteine Protease / Tbc1 Domain Family Member 3c

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Tbc1 Domain Family Member 3c

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.26   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 26   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.26   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0