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Tdark
CYB5RL
NADH-cytochrome b5 reductase-like

Protein Summary
Description
NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287899
  • ENSP00000287899
  • ENSG00000215883
  • ENST00000534324
  • ENSP00000434343
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
histone modification site profile
0.69
tissue sample
0.59
microRNA
0.57
gene perturbation
0.56


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.07   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 31   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.07   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1919657
230582
Dog
cytochrome b5 reductase like
VGNC:50305
610595
Anole lizard
NADH-cytochrome b5 reductase-like
100565827
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
cytochrome b5 reductase like
Anole lizard
NADH-cytochrome b5 reductase-like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6IPT4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Erythrocytes take up carbon dioxide and release oxygen (R-HSA-1237044)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Erythrocytes take up carbon dioxide and release oxygen
Reactome
O2/CO2 exchange in erythrocytes
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Erythrocytes take up carbon dioxide and release oxygen
O2/CO2 exchange in erythrocytes
Transport of small molecules
Protein-Protein Interactions (21)
1 – 10 of 21
HBB
Tbio
Novelty: 0.00049683
Score: 0.905
Data Source: Reactome,STRINGDB
CYB5A
Tbio
Novelty: 0.00047376
Score: 0.84
Data Source: STRINGDB
POR
Tbio
Family: Enzyme
Novelty: 0.00145147
Score: 0.763
Data Source: STRINGDB
ZNF714
Tdark
Family: TF
Novelty: 0.73743398
Score: 0.659
Data Source: STRINGDB
C8orf44
Tdark
Novelty: 4.22913257
Score: 0.646
Data Source: STRINGDB
ATAD3C
Tdark
Family: Enzyme
Novelty: 0.33587655
Score: 0.635
Data Source: STRINGDB
FDXR
Tbio
Family: Enzyme
Novelty: 0.00171588
Score: 0.62
Data Source: STRINGDB
MOCOS
Tbio
Family: Enzyme
Novelty: 0.05022905
Score: 0.537
Data Source: STRINGDB
NFS1
Tbio
Family: Enzyme
Novelty: 0.01274706
Score: 0.535
Data Source: STRINGDB
NANS
Tbio
Family: Enzyme
Novelty: 0.00718044
Score: 0.513
Data Source: STRINGDB
Publication Statistics
PubMed Score  4.07

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer