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Tdark
IQCE
IQ domain-containing protein E

Protein Summary
Description
Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325979
  • ENSP00000313772
  • ENSG00000106012
  • ENST00000402050
  • ENSP00000385597
  • ENST00000404984
  • ENSP00000385945
  • ENST00000438376
  • ENSP00000396178
  • ENST00000623361
  • ENSP00000485601

Symbol
  • KIAA1023
  • PAPA7
  • 1700028P05Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
cell type or tissue
0.6
transcription factor binding site profile
0.6
virus perturbation
0.59
cell line
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.99   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.99   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
TTC23L
Tdark
Novelty:  0.36199095
p_int:  0.999999732
p_ni:  1.32e-7
p_wrong:  1.36e-7
Score:  0.485
Data Source:  BioPlex,STRINGDB
MYL12B
Tbio
Novelty:  0.00999083
p_int:  0.999994362
p_ni:  0.000003014
p_wrong:  0.000002624
Data Source:  BioPlex
RFFL
Tbio
Family:  Enzyme
Novelty:  0.06621524
p_int:  0.999938609
p_ni:  0.000022439
p_wrong:  0.000038953
Score:  0.54
Data Source:  BioPlex,STRINGDB
EFCAB7
Tdark
Novelty:  0.36952617
Score:  0.987
Data Source:  Reactome,STRINGDB
EVC2
Tbio
Novelty:  0.01398469
Score:  0.958
Data Source:  Reactome,STRINGDB
EVC
Tbio
Novelty:  0.02171391
Score:  0.953
Data Source:  Reactome,STRINGDB
TMEM186
Tdark
Novelty:  0.59951294
Score:  0.729
Data Source:  STRINGDB
PHYHIPL
Tdark
Family:  Enzyme
Novelty:  1.63617414
Score:  0.695
Data Source:  STRINGDB
TMEM143
Tdark
Novelty:  1.58941369
Score:  0.67
Data Source:  STRINGDB
ARMC4
Tbio
Novelty:  0.17860406
Score:  0.66
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Activation of SMO (R-HSA-5635838)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of SMO
Reactome
Hedgehog 'on' state
Reactome
Signal Transduction
Reactome
Signaling by Hedgehog
Name
Explore in Pharos
Explore in Source
Activation of SMO
Hedgehog 'on' state
Signal Transduction
Signaling by Hedgehog
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
5
6
88.7
hematocrit
2
2
2
62
mean platelet volume
2
1
2
57.3
reticulocyte measurement
3
2
3
56.6
BMI-adjusted waist circumference
1
1
1
46.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
6
88.7
hematocrit
2
62
mean platelet volume
2
57.3
reticulocyte measurement
3
56.6
BMI-adjusted waist circumference
1
46.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
IQ motif containing E
VGNC:4403
463230
Macaque
IQ motif containing E
714253
Mouse
MGI:1921489
74239
Rat
RGD:1311349
304318
Dog
IQ motif containing E
VGNC:42076
489889
Species
Name
OMA
EggNOG
Inparanoid
Chimp
IQ motif containing E
Macaque
IQ motif containing E
Mouse
Rat
Dog
IQ motif containing E
Publication Statistics
PubMed Score 3.99
PubMed score by year
PubTator Score 1.23
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title