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Tbio
PPP4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

Protein Summary
Description
Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000554684
  • ENSP00000450864
  • ENSG00000100796
  • ENST00000554943
  • ENSP00000450883
  • ENST00000555462
  • ENSP00000450891

Symbol
  • KIAA2010
  • PP4R3A
  • SMEK1
  • smk1
  • FLFL1
  • PP4R3
  • SMEK1
  • smk-1
  • PP4R3A
  • MSTP033
  • KIAA2010
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.16   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.16   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1
2
1
77.1
red blood cell density measurement
1
1
1
41.8
mean reticulocyte volume
1
1
1
37.2
cingulate cortex measurement
1
2
0
1.3
33.9
glucose metabolism decline measurement
1
2
0
1.3
33.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
77.1
red blood cell density measurement
1
41.8
mean reticulocyte volume
1
37.2
cingulate cortex measurement
0
1.3
33.9
glucose metabolism decline measurement
0
1.3
33.9
Gene Ontology Terms (3)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (89)
1 – 10 of 89
PPP4R2
Tbio
Family: Enzyme
Novelty: 0.15136638
p_int: 1
Score: 0.991
Data Source: BioPlex,STRINGDB
PPP4R3B
Tbio
Family: Enzyme
Novelty: 0.0185504
p_int: 0.999988258
p_ni: 0.000011724
p_wrong: 1.8e-8
Score: 0.965
Data Source: BioPlex,STRINGDB
PMPCB
Tbio
Family: Enzyme
Novelty: 0.0244013
p_int: 0.999810571
p_ni: 0.000189429
Score: 0.328
Data Source: BioPlex,STRINGDB
LRRTM4
Tbio
Novelty: 0.07741851
p_int: 0.999249034
p_ni: 0.000750966
Data Source: BioPlex
USP10
Tchem
Family: Enzyme
Novelty: 0.05830541
p_int: 0.99831525
p_ni: 0.001684747
p_wrong: 3e-9
Score: 0.421
Data Source: BioPlex,STRINGDB
ZNF785
Tdark
Family: TF
Novelty: 0.42629766
p_int: 0.998044892
p_ni: 0.001955104
p_wrong: 4e-9
Data Source: BioPlex
TSSC4
Tdark
Novelty: 0.17064786
p_int: 0.997629233
p_ni: 0.002370754
p_wrong: 1.3e-8
Score: 0.15
Data Source: BioPlex,STRINGDB
CRAMP1
Tdark
Novelty: 0.26519971
p_int: 0.997379114
p_ni: 0.002620876
p_wrong: 1.1e-8
Score: 0.571
Data Source: BioPlex,STRINGDB
PPP4C
Tbio
Family: Enzyme
Novelty: 0.00705824
p_int: 0.997069252
p_ni: 0.002930748
Score: 0.997
Data Source: BioPlex,STRINGDB
MARCKSL1
Tbio
Novelty: 0.01290798
p_int: 0.996862954
p_ni: 0.003137046
Score: 0.293
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  26.16

PubMed score by year
PubTator Score  4.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer