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Tbio
MRM1
rRNA methyltransferase 1, mitochondrial

Protein Summary
Description
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1145 (Gm1145) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000611231
  • ENSP00000478520
  • ENSG00000274853
  • ENST00000614766
  • ENSP00000481559
  • ENSG00000278619
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.9
transcription factor binding site profile
0.88
protein domain
0.85
tissue sample
0.71
small molecule perturbation
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.73   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.73   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
89.3
body mass index
1
1
1
89.3
macrophage inflammatory protein 1b measurement
1
2
2
82
macrophage inflammatory protein 1b measurement
1
1
1
81.1
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
89.3
body mass index
1
89.3
macrophage inflammatory protein 1b measurement
2
82
macrophage inflammatory protein 1b measurement
1
81.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2443470
217038
Rat
RGD:1566232
363661
Dog
mitochondrial rRNA methyltransferase 1
VGNC:43366
610311
Cow
mitochondrial rRNA methyltransferase 1
VGNC:31605
526282
Pig
mitochondrial rRNA methyltransferase 1
100513493
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
mitochondrial rRNA methyltransferase 1
Cow
mitochondrial rRNA methyltransferase 1
Pig
mitochondrial rRNA methyltransferase 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6IN84-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
rRNA modification in the mitochondrion
Reactome
rRNA processing
Reactome
rRNA processing in the mitochondrion
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
rRNA modification in the mitochondrion
rRNA processing
rRNA processing in the mitochondrion
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (114)
1 – 10 of 114
CGGBP1
Tbio
Novelty: 0.10880271
p_int: 0.999864444
p_ni: 0.000131028
p_wrong: 0.000004528
Score: 0.157
Data Source: BioPlex,STRINGDB
UBR1
Tbio
Family: Enzyme
Novelty: 0.00998888
p_int: 0.999523778
p_ni: 0.000476222
Data Source: BioPlex
GRPEL2
Tdark
Novelty: 0.52660174
p_int: 0.999405653
p_ni: 0.000593601
p_wrong: 7.45e-7
Score: 0.677
Data Source: BioPlex,STRINGDB
SELENOO
Tdark
Novelty: 0.02959704
p_int: 0.998601449
p_ni: 0.001397379
p_wrong: 0.000001172
Data Source: BioPlex
ATE1
Tbio
Family: Enzyme
Novelty: 0.01672896
p_int: 0.998192114
p_ni: 0.001807886
Score: 0.212
Data Source: BioPlex,STRINGDB
ZZEF1
Tdark
Novelty: 0.33216648
p_int: 0.99794922
p_ni: 0.00205078
Data Source: BioPlex
ZYG11B
Tbio
Novelty: 0.14657862
p_int: 0.997541621
p_ni: 0.002458379
Data Source: BioPlex
ATPAF2
Tbio
Family: Enzyme
Novelty: 0.04184643
p_int: 0.997541541
p_ni: 0.001995765
p_wrong: 0.000462694
Score: 0.402
Data Source: BioPlex,STRINGDB
DBT
Tbio
Family: Enzyme
Novelty: 0.0070589
p_int: 0.99536887
p_ni: 0.00463113
Score: 0.23
Data Source: BioPlex,STRINGDB
MRPL12
Tbio
Novelty: 0.10646542
p_int: 0.993005939
p_ni: 0.006994061
Score: 0.514
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  12.73

PubMed score by year
PubTator Score  1.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer