Tbio MRM1 rRNA methyltransferase 1, mitochondrial

Protein Summary

Description

S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1145 (Gm1145) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.

Uniprot Accession IDs

• Q6IN84
• A8K8E2
• Q96GK2
• Q9H664

Gene Name

• MRM1

Ensembl ID

• ENST00000611231
• ENSP00000478520
• ENSG00000274853
• ENST00000614766
• ENSP00000481559
• ENSG00000278619

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.9
transcription factor binding site profile	0.88
protein domain	0.85
tissue sample	0.71
small molecule perturbation	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.58   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 114   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.58   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0