Tbio JADE1 Protein Jade-1

Protein Summary

Description

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function.

Uniprot Accession IDs

• Q6IE81
• D3DNY0
• D3DNY1
• Q4W5D5
• Q6ZSL7
• Q8NC41
• Q96JL8
• Q96SQ1
• Q9H692

Gene Name

• JADE1

Ensembl ID

• ENST00000226319
• ENSP00000226319
• ENSG00000077684
• ENST00000413543
• ENSP00000404211
• ENST00000452328
• ENSP00000388015
• ENST00000511647
• ENSP00000423737
• ENST00000512960
• ENSP00000425730
• ENST00000610919
• ENSP00000483219
• ENST00000611140
• ENSP00000482212

Symbol

• KIAA1807
• PHF17
• PHF17

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
transcription factor perturbation	0.99
microRNA	0.96
transcription factor binding site profile	0.93
transcription factor	0.87

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Protein Jade-1

Protein / Nucleic Acid Binding / Protein Jade-1

DTO Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Protein Jade-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.47   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 176   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.47   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (48)

Explore Interacting Targets

1 – 10 of 48

• See Interactions on String-DB

KAT7

Tbio

Family:  TF; Epigenetic

Novelty:  0.01783137

p_int:  1

Score:  0.995

Data Source:  BioPlex,Reactome,STRINGDB

MEAF6

Tbio

Novelty:  0.0914094

p_int:  0.999999983

p_ni:  1.1e-8

p_wrong:  6e-9

Score:  0.991

Data Source:  BioPlex,Reactome,STRINGDB

ING5

Tbio

Family:  Epigenetic

Novelty:  0.03585867

Score:  0.972

Data Source:  Reactome,STRINGDB

ING4

Tbio

Family:  Epigenetic

Novelty:  0.01372992

Score:  0.971

Data Source:  Reactome,STRINGDB

NPHP4

Tbio

Novelty:  0.02873746

Score:  0.765

Data Source:  STRINGDB

HIST1H4A

Tchem

Novelty:  0.00279614

Score:  0.75

Data Source:  STRINGDB

VHL

Tchem

Family:  Enzyme

Novelty:  0.00285782

Score:  0.727

Data Source:  STRINGDB

CTNNB1

Tchem

Novelty:  0.0000744

Score:  0.704

Data Source:  STRINGDB

KAT5

Tchem

Family:  Epigenetic

Novelty:  0.00368348

Score:  0.689

Data Source:  STRINGDB

PPP3R2

Tbio

Novelty:  0.01121867

Score:  0.556

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

Reactome (3)

Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Chromatin modifying enzymes	238 targets	R-HSA-3247509
Reactome	Chromatin organization	238 targets	R-HSA-4839726
Reactome	HATs acetylate histones	107 targets	R-HSA-3214847

Name	Explore in Pharos	Explore in Source
Chromatin modifying enzymes	238 targets	R-HSA-3247509
Chromatin organization	238 targets	R-HSA-4839726
HATs acetylate histones	107 targets	R-HSA-3214847

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (18)

Functions (2)

Components (8)

Processes (8)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
transcription coactivator activity	Inferred from Direct Assay (IDA)	MGI
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	3	1	3		61.4
self reported educational attainment	EFO_0004784	1	1	1		24.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	3		61.4
self reported educational attainment	EFO_0004784	1		24.5

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Activator
Alternative splicing
Apoptosis
Cell projection
Complete proteome
Cytoplasm
Cytoskeleton
Isopeptide bond
Metal-binding

GWAS Trait Find Similar Targets

No Header	No Header
mathematical ability
self reported educational attainment

MGI Phenotype Find Similar Targets

No Header	No Header
mortality/aging
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	jade family PHD finger 1	VGNC:620	461484
Macaque	jade family PHD finger 1		693690
Mouse	jade family PHD finger 1	MGI:1925835	269424
Rat	jade family PHD finger 1	RGD:1306920	310352
Dog	jade family PHD finger 1	VGNC:42169	483830

Species	Name	OMA	EggNOG	Inparanoid
Chimp	jade family PHD finger 1
Macaque	jade family PHD finger 1
Mouse	jade family PHD finger 1
Rat	jade family PHD finger 1
Dog	jade family PHD finger 1

Publication Statistics

PubMed Score 19.47

PubMed score by year

Reset Zoom

PubTator Score 9.81

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (31)

GeneRif Annotations (17)

Items per page:

10

0 of 0

PMID	Year	Title