Protein Summary
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function.
- ENST00000226319
- ENSP00000226319
- ENSG00000077684
- ENST00000413543
- ENSP00000404211
- ENST00000452328
- ENSP00000388015
- ENST00000511647
- ENSP00000423737
- ENST00000512960
- ENSP00000425730
- ENST00000610919
- ENSP00000483219
- ENST00000611140
- ENSP00000482212
- KIAA1807
- PHF17
- PHF17
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 1 | ||
transcription factor perturbation | 0.99 | ||
microRNA | 0.96 | ||
transcription factor binding site profile | 0.93 | ||
transcription factor | 0.87 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.47 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 176 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.47 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 176 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (48)
1 – 10 of 48
KAT7
Family: TF; Epigenetic
Novelty: 0.01783137
p_int: 1
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
MEAF6
Novelty: 0.0914094
p_int: 0.999999983
p_ni: 1.1e-8
p_wrong: 6e-9
Score: 0.991
Data Source: BioPlex,Reactome,STRINGDB
ING5
Family: Epigenetic
Novelty: 0.03585867
Score: 0.972
Data Source: Reactome,STRINGDB
ING4
Family: Epigenetic
Novelty: 0.01372992
Score: 0.971
Data Source: Reactome,STRINGDB
NPHP4
Novelty: 0.02873746
Score: 0.765
Data Source: STRINGDB
HIST1H4A
Novelty: 0.00279614
Score: 0.75
Data Source: STRINGDB
VHL
Family: Enzyme
Novelty: 0.00285782
Score: 0.727
Data Source: STRINGDB
CTNNB1
Novelty: 0.0000744
Score: 0.704
Data Source: STRINGDB
KAT5
Family: Epigenetic
Novelty: 0.00368348
Score: 0.689
Data Source: STRINGDB
PPP3R2
Novelty: 0.01121867
Score: 0.556
Data Source: STRINGDB
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 3 of 3
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Chromatin modifying enzymes | ||||
Reactome | Chromatin organization | ||||
Reactome | HATs acetylate histones | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Chromatin modifying enzymes | ||||
Chromatin organization | ||||
HATs acetylate histones | ||||
Gene Ontology Terms (18)
Functions (2)
Components (8)
Processes (8)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mathematical ability | 3 | 1 | 3 | 61.4 | |||||
self reported educational attainment | 1 | 1 | 1 | 24.5 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mathematical ability | 3 | 61.4 | |||||
self reported educational attainment | 1 | 24.5 | |||||
Find similar targets by:
UniProt Keyword
No Header | No Header | ||
|---|---|---|---|
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | jade family PHD finger 1 | VGNC:620 | 461484 | |||||
Macaque | jade family PHD finger 1 | 693690 | ||||||
Mouse | MGI:1925835 | 269424 | ||||||
Rat | RGD:1306920 | 310352 | ||||||
Dog | jade family PHD finger 1 | VGNC:42169 | 483830 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | jade family PHD finger 1 | |||||
Macaque | jade family PHD finger 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | jade family PHD finger 1 | |||||
Publication Statistics
PubMed Score 19.47
PubMed score by year
PubTator Score 9.81
PubTator score by year