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Tbio
JADE1
Protein Jade-1

Protein Summary
Description
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226319
  • ENSP00000226319
  • ENSG00000077684
  • ENST00000413543
  • ENSP00000404211
  • ENST00000452328
  • ENSP00000388015
  • ENST00000511647
  • ENSP00000423737
  • ENST00000512960
  • ENSP00000425730
  • ENST00000610919
  • ENSP00000483219
  • ENST00000611140
  • ENSP00000482212

Symbol
  • KIAA1807
  • PHF17
  • PHF17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.99
microRNA
0.96
transcription factor binding site profile
0.93
transcription factor
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.47   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.47   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (48)
1 – 10 of 48
KAT7
Tbio
Family:  TF; Epigenetic
Novelty:  0.01783137
p_int:  1
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
MEAF6
Tbio
Novelty:  0.0914094
p_int:  0.999999983
p_ni:  1.1e-8
p_wrong:  6e-9
Score:  0.991
Data Source:  BioPlex,Reactome,STRINGDB
ING5
Tbio
Family:  Epigenetic
Novelty:  0.03585867
Score:  0.972
Data Source:  Reactome,STRINGDB
ING4
Tbio
Family:  Epigenetic
Novelty:  0.01372992
Score:  0.971
Data Source:  Reactome,STRINGDB
NPHP4
Tbio
Novelty:  0.02873746
Score:  0.765
Data Source:  STRINGDB
HIST1H4A
Tchem
Novelty:  0.00279614
Score:  0.75
Data Source:  STRINGDB
VHL
Tchem
Family:  Enzyme
Novelty:  0.00285782
Score:  0.727
Data Source:  STRINGDB
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.704
Data Source:  STRINGDB
KAT5
Tchem
Family:  Epigenetic
Novelty:  0.00368348
Score:  0.689
Data Source:  STRINGDB
PPP3R2
Tbio
Novelty:  0.01121867
Score:  0.556
Data Source:  STRINGDB
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Gene Ontology Terms (18)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
1
3
61.4
self reported educational attainment
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
61.4
self reported educational attainment
1
24.5
Find similar targets by:
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
jade family PHD finger 1
VGNC:620
461484
Macaque
jade family PHD finger 1
693690
Mouse
MGI:1925835
269424
Rat
RGD:1306920
310352
Dog
jade family PHD finger 1
VGNC:42169
483830
Species
Name
OMA
EggNOG
Inparanoid
Chimp
jade family PHD finger 1
Macaque
jade family PHD finger 1
Mouse
Rat
Dog
jade family PHD finger 1
Publication Statistics
PubMed Score 19.47
PubMed score by year
PubTator Score 9.81
PubTator score by year