Tdark DESI1 Desumoylating isopeptidase 1

Protein Summary

Description

Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity. Desumoylates ZBTB46 (By similarity).

Uniprot Accession IDs

• Q6ICB0
• DeSI-1

Gene Name

• DESI1

Ensembl ID

• ENST00000263256
• ENSP00000263256
• ENSG00000100418

Symbol

• FAM152B
• PPPDE2
• DESI2
• DeSI-1
• PPPDE2
• FAM152B
• D15Wsu75e
• DJ347H13.4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
disease perturbation	0.98
histone modification site profile	0.92
transcription factor perturbation	0.8
microRNA	0.76

Protein Classes

PANTHER Classes

Protein / ... / Cysteine Protease / Desumoylating Isopeptidase 1

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Desumoylating Isopeptidase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.05   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 28   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.05   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0