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Tbio
TWF2
Twinfilin-2

Protein Summary
Description
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity). The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305533
  • ENSP00000303908
  • ENSG00000247596

Symbol
  • PTK9L
  • A6r
  • A6RP
  • PTK9L
  • MSTP011
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
transcription factor binding site profile
0.79
biological process
0.77
transcription factor perturbation
0.74
cell type or tissue
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.96   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.96   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
worry measurement
2
1
1
6
80.4
feeling nervous measurement
1
1
0
6
23.4
1
1
0
1.1
8.1
1
1
0
1.1
8.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
worry measurement
1
6
80.4
feeling nervous measurement
0
6
23.4
0
1.1
8.1
0
1.1
8.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1346078
23999
Dog
twinfilin actin binding protein 2
VGNC:49952
111089970
Pig
twinfilin actin binding protein 2
106504190
Opossum
twinfilin actin binding protein 2
100020777
Platypus
twinfilin actin binding protein 2
100079621
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
twinfilin actin binding protein 2
Pig
twinfilin actin binding protein 2
Opossum
twinfilin actin binding protein 2
Platypus
twinfilin actin binding protein 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q6IBS0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (29)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Protein-Protein Interactions (68)
1 – 10 of 68
CAP2
Tbio
Family: Enzyme
Novelty: 0.1142507
p_int: 0.999961518
p_ni: 0.000038482
Score: 0.904
Data Source: BioPlex,STRINGDB
CAP1
Tbio
Family: Enzyme
Novelty: 0.0333464
p_int: 0.99618401
p_ni: 0.00381599
Score: 0.921
Data Source: BioPlex,STRINGDB
ACTBL2
Tbio
Novelty: 0.18080702
p_int: 0.993413042
p_ni: 0.006586958
Score: 0.547
Data Source: BioPlex,STRINGDB
BCL7C
Tdark
Novelty: 0.31203802
p_int: 0.976989411
p_ni: 0.023010589
Score: 0.741
Data Source: BioPlex,STRINGDB
BCL7A
Tbio
Novelty: 0.07026394
p_int: 0.969552183
p_ni: 0.030447817
Score: 0.555
Data Source: BioPlex,STRINGDB
TMOD3
Tbio
Novelty: 0.04744699
p_int: 0.950464546
p_ni: 0.049535454
Score: 0.758
Data Source: BioPlex,STRINGDB
ACTA2
Tbio
Novelty: 0.00199354
p_int: 0.905227303
p_ni: 0.094772698
Score: 0.768
Data Source: BioPlex,STRINGDB
ACTB
Tbio
Novelty: 0.00006048
p_int: 0.90413738
p_ni: 0.09586262
Score: 0.806
Data Source: BioPlex,STRINGDB
ACTC1
Tbio
Novelty: 0.00188036
p_int: 0.816703586
p_ni: 0.183296414
Score: 0.825
Data Source: BioPlex,STRINGDB
UTP6
Tbio
Novelty: 0.06525007
Score: 0.942
Data Source: STRINGDB
Publication Statistics
PubMed Score  24.96

PubMed score by year
PubTator Score  7.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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