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Tbio
GLYAT
Glycine N-acyltransferase

Protein Summary
Description
Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid. The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoA's. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278400
  • ENSP00000278400
  • ENSG00000149124
  • ENST00000344743
  • ENSP00000340200
  • ENST00000529732
  • ENSP00000431688
  • ENST00000611865
  • ENSP00000484592

Symbol
  • ACGNAT
  • CAT
  • GAT
  • CAT
  • GAT
  • ACGNAT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.66
kinase perturbation
0.66
cellular component
0.63
microRNA
0.62
pathway
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.71   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.71   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
66.2
1
1
0
1.1
58.3
1
1
0
1.1
34.7
Agents acting on the renin-angiotensin system use measurement
1
1
1
26.3
HMG CoA reductase inhibitor use measurement
1
1
1
10.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
66.2
0
1.1
58.3
0
1.1
34.7
Agents acting on the renin-angiotensin system use measurement
1
26.3
HMG CoA reductase inhibitor use measurement
1
10.6
Pathways (11)
Amino Acid conjugation (R-HSA-156587)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino Acid conjugation
Reactome
Biological oxidations
Reactome
Conjugation of benzoate with glycine
Reactome
Conjugation of carboxylic acids
Reactome
Conjugation of salicylate with glycine
Name
Explore in Pharos
Explore in Source
Amino Acid conjugation
Biological oxidations
Conjugation of benzoate with glycine
Conjugation of carboxylic acids
Conjugation of salicylate with glycine
Protein-Protein Interactions (41)
1 – 10 of 41
GUCY2C
Tclin
Family: Kinase
Novelty: 0.00209733
Score: 0.866
Data Source: STRINGDB
GAA
Tclin
Family: Enzyme
Novelty: 0.0063246
Score: 0.865
Data Source: STRINGDB
TSHZ1
Tbio
Family: TF
Novelty: 0.02155224
Score: 0.86
Data Source: STRINGDB
AGA
Tbio
Family: Enzyme
Novelty: 0.01522819
Score: 0.858
Data Source: STRINGDB
GGCT
Tchem
Family: Enzyme
Novelty: 0.01154389
Score: 0.855
Data Source: STRINGDB
DOCK11
Tdark
Novelty: 0.0295159
Score: 0.838
Data Source: STRINGDB
FLVCR2
Tbio
Novelty: 0.02871146
Score: 0.832
Data Source: STRINGDB
UGT8
Tbio
Family: Enzyme
Novelty: 0.02518383
Score: 0.832
Data Source: STRINGDB
GGT1
Tbio
Family: Enzyme
Novelty: 0.00252374
Score: 0.805
Data Source: STRINGDB
GCA
Tbio
Novelty: 0.01485875
Score: 0.804
Data Source: STRINGDB
Publication Statistics
PubMed Score  47.71

PubMed score by year
PubTator Score  508.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer