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Tbio
LAMTOR1
Ragulator complex protein LAMTOR1

Protein Summary
Description
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278671
  • ENSP00000278671
  • ENSG00000149357

Symbol
  • C11orf59
  • PDRO
  • p18
  • PDRO
  • C11orf59
  • p27RF-Rho
  • Ragulator1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
small molecule perturbation
0.82
transcription factor binding site profile
0.8
transcription factor perturbation
0.8
biological process
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.44   (req: < 5)
View Publications
Gene RIFs: 11   (req: <= 3)
View Gene RIFs
Antibodies: 71   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.44   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (20)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
109 targets
R-HSA-9612973
Reactome
Cellular responses to external stimuli
487 targets
R-HSA-8953897
Reactome
Energy dependent regulation of mTOR by LKB1-AMPK
28 targets
R-HSA-380972
Reactome
Gene expression (Transcription)
1452 targets
R-HSA-74160
Reactome
Generic Transcription Pathway
1195 targets
R-HSA-212436
Name
Explore in Pharos
Explore in Source
Autophagy
109 targets
R-HSA-9612973
Cellular responses to external stimuli
487 targets
R-HSA-8953897
Energy dependent regulation of mTOR by LKB1-AMPK
28 targets
R-HSA-380972
Gene expression (Transcription)
1452 targets
R-HSA-74160
Generic Transcription Pathway
1195 targets
R-HSA-212436
Gene Ontology Terms (28)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
GTPase binding
Inferred from Physical Interaction (IPI)
CAFA
Protein-Protein Interactions (235)
1 – 10 of 235
ALG2
Tbio
Family: Enzyme
Novelty: 0.04124015
p_int: 0.999999937
p_ni: 5.9e-8
p_wrong: 3e-9
Data Source: BioPlex
RRAGD
Tbio
Novelty: 0.08337222
p_int: 0.99999989
p_ni: 1.1e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
SLC38A9
Tbio
Family: Transporter
Novelty: 0.11535293
p_int: 0.999994177
p_ni: 0.000005823
Score: 0.999
Data Source: BioPlex,STRINGDB
RRAGB
Tbio
Novelty: 0.03689523
p_int: 0.999988238
p_ni: 0.000011762
Score: 0.999
Data Source: BioPlex,STRINGDB
RRAGC
Tbio
Novelty: 0.02924575
p_int: 0.999981584
p_ni: 0.000018411
p_wrong: 5e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
BORCS5
Tdark
Novelty: 0.88002186
p_int: 0.999978652
p_ni: 0.000021348
Data Source: BioPlex
BORCS7
Tdark
Novelty: 0.2115869
p_int: 0.999877964
p_ni: 0.000122036
Data Source: BioPlex
BORCS8
Tdark
Novelty: 1.84210526
p_int: 0.999739818
p_ni: 0.000260182
p_wrong: 1e-9
Data Source: BioPlex
BORCS6
Tdark
Novelty: 0.68965517
p_int: 0.99954071
p_ni: 0.000459291
Score: 0.458
Data Source: BioPlex,STRINGDB
PRKAA1
Tclin
Family: Kinase
Novelty: 0.01012358
p_int: 0.998877618
p_ni: 0.001122382
Score: 0.902
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  18.44

PubMed score by year
PubTator Score  10.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer