LAMTOR1
Ragulator complex protein LAMTOR1
Protein Summary
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.
- ENST00000278671
- ENSP00000278671
- ENSG00000149357
- C11orf59
- PDRO
- p18
- PDRO
- C11orf59
- p27RF-Rho
- Ragulator1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.84 | ||
small molecule perturbation | 0.82 | ||
transcription factor binding site profile | 0.8 | ||
transcription factor perturbation | 0.8 | ||
biological process | 0.71 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.65 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 71 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.65 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 71 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 | VGNC:8278 | 451399 | |||||
Macaque | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 | 718249 | ||||||
Mouse | MGI:1913758 | 66508 | ||||||
Rat | RGD:735078 | 308869 | ||||||
Dog | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 | VGNC:42577 | 485211 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 | |||||
Macaque | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 | |||||
Protein Structure (7 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 7
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (20)
Reactome (19)
KEGG (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 19
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Autophagy | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Energy dependent regulation of mTOR by LKB1-AMPK | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Autophagy | ||||
Cellular responses to external stimuli | ||||
Energy dependent regulation of mTOR by LKB1-AMPK | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Gene Ontology Terms (28)
Functions (1)
Components (10)
Processes (17)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | CAFA | |||
Protein-Protein Interactions (235)
1 – 10 of 235
ALG2
Family: Enzyme
Novelty: 0.03804805
p_int: 0.999999937
p_ni: 5.9e-8
p_wrong: 3e-9
Data Source: BioPlex
RRAGD
Novelty: 0.04742375
p_int: 0.99999989
p_ni: 1.1e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
SLC38A9
Family: Transporter
Novelty: 0.0879703
p_int: 0.999994177
p_ni: 0.000005823
Score: 0.999
Data Source: BioPlex,STRINGDB
RRAGB
Novelty: 0.02279777
p_int: 0.999988238
p_ni: 0.000011762
Score: 0.999
Data Source: BioPlex,STRINGDB
RRAGC
Novelty: 0.01462756
p_int: 0.999981584
p_ni: 0.000018411
p_wrong: 5e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
BORCS5
Novelty: 0.59333419
p_int: 0.999978652
p_ni: 0.000021348
Data Source: BioPlex
BORCS7
Novelty: 0.14135922
p_int: 0.999877964
p_ni: 0.000122036
Data Source: BioPlex
BORCS8
Novelty: 1.62939642
p_int: 0.999739818
p_ni: 0.000260182
p_wrong: 1e-9
Data Source: BioPlex
BORCS6
Novelty: 0.83789033
p_int: 0.99954071
p_ni: 0.000459291
Score: 0.458
Data Source: BioPlex,STRINGDB
PRKAA1
Family: Kinase
Novelty: 0.01205826
p_int: 0.998877618
p_ni: 0.001122382
Score: 0.902
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 23.65
PubMed score by year
PubTator Score 10.71
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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