Tbio LAMTOR1 Ragulator complex protein LAMTOR1

Protein Summary

Description

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.

Uniprot Accession IDs

• Q6IAA8
• Q8WZ09
• Q9NWT0

Gene Name

• LAMTOR1

Ensembl ID

• ENST00000278671
• ENSP00000278671
• ENSG00000149357

Symbol

• C11orf59
• PDRO
• p18
• PDRO
• C11orf59
• p27RF-Rho
• Ragulator1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.84
small molecule perturbation	0.82
transcription factor binding site profile	0.8
transcription factor perturbation	0.8
biological process	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.99   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 71   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.99   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (235)

Explore Interacting Targets

1 – 10 of 235

• See Interactions on String-DB

ALG2

Tbio

Family:  Enzyme

Novelty:  0.03804805

p_int:  0.999999937

p_ni:  5.9e-8

p_wrong:  3e-9

Data Source:  BioPlex

RRAGD

Tbio

Novelty:  0.04742375

p_int:  0.99999989

p_ni:  1.1e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

SLC38A9

Tbio

Family:  Transporter

Novelty:  0.0879703

p_int:  0.999994177

p_ni:  0.000005823

Score:  0.999

Data Source:  BioPlex,STRINGDB

RRAGB

Tbio

Novelty:  0.02279777

p_int:  0.999988238

p_ni:  0.000011762

Score:  0.999

Data Source:  BioPlex,STRINGDB

RRAGC

Tbio

Novelty:  0.01462756

p_int:  0.999981584

p_ni:  0.000018411

p_wrong:  5e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

BORCS5

Tdark

Novelty:  0.59333419

p_int:  0.999978652

p_ni:  0.000021348

Data Source:  BioPlex

BORCS7

Tbio

Novelty:  0.14135922

p_int:  0.999877964

p_ni:  0.000122036

Data Source:  BioPlex

BORCS8

Tdark

Novelty:  1.62939642

p_int:  0.999739818

p_ni:  0.000260182

p_wrong:  1e-9

Data Source:  BioPlex

BORCS6

Tdark

Novelty:  0.83789033

p_int:  0.99954071

p_ni:  0.000459291

Score:  0.458

Data Source:  BioPlex,STRINGDB

PRKAA1

Tclin

Family:  Kinase

Novelty:  0.01205826

p_int:  0.998877618

p_ni:  0.001122382

Score:  0.902

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (20)

Reactome (19)

KEGG (1)

Autophagy (R-HSA-9612973)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Autophagy	109 targets	R-HSA-9612973
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897
Reactome	Energy dependent regulation of mTOR by LKB1-AMPK	28 targets	R-HSA-380972
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436

Name	Explore in Pharos	Explore in Source
Autophagy	109 targets	R-HSA-9612973
Cellular responses to external stimuli	487 targets	R-HSA-8953897
Energy dependent regulation of mTOR by LKB1-AMPK	28 targets	R-HSA-380972
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (28)

Functions (1)

Components (10)

Processes (17)

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GO Term	Evidence	Assigned by
GTPase binding	Inferred from Physical Interaction (IPI)	CAFA

Disease Associations ()

No disease associations found

GWAS Traits (1)

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1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
calcium measurement	EFO_0004838	1	1	1		31.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
calcium measurement	EFO_0004838	1		31.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Cell membrane
Complete proteome
Direct protein sequencing
Endosome
Lipoprotein
Lysosome
Membrane
Myristate
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
calcium measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
embryo phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1	VGNC:8278	451399
Macaque	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1		718249
Mouse	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1	MGI:1913758	66508
Rat	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1	RGD:735078	308869
Dog	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1	VGNC:42577	485211

Species	Name	OMA	EggNOG	Inparanoid
Chimp	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Macaque	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Mouse	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Rat	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Dog	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1

Publication Statistics

PubMed Score 25.99

PubMed score by year

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PubTator Score 10.71

PubTator score by year

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Related Publications

Text Mined References (26)

GeneRif Annotations (11)

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PMID	Year	Title