You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
LAMTOR1
Ragulator complex protein LAMTOR1

Protein Summary
Description
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278671
  • ENSP00000278671
  • ENSG00000149357

Symbol
  • C11orf59
  • PDRO
  • p18
  • PDRO
  • C11orf59
  • p27RF-Rho
  • Ragulator1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
small molecule perturbation
0.82
transcription factor binding site profile
0.8
transcription factor perturbation
0.8
biological process
0.71


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.65   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.65   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
VGNC:8278
451399
Macaque
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
718249
Mouse
MGI:1913758
66508
Rat
RGD:735078
308869
Dog
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
VGNC:42577
485211
Species
Name
OMA
EggNOG
Inparanoid
Chimp
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Macaque
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Mouse
Rat
Dog
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q6IAA8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (20)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Energy dependent regulation of mTOR by LKB1-AMPK
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Energy dependent regulation of mTOR by LKB1-AMPK
Gene expression (Transcription)
Generic Transcription Pathway
Gene Ontology Terms (28)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
CAFA
Protein-Protein Interactions (235)
1 – 10 of 235
ALG2
Tbio
Family: Enzyme
Novelty: 0.03804805
p_int: 0.999999937
p_ni: 5.9e-8
p_wrong: 3e-9
Data Source: BioPlex
RRAGD
Tbio
Novelty: 0.04742375
p_int: 0.99999989
p_ni: 1.1e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
SLC38A9
Tbio
Family: Transporter
Novelty: 0.0879703
p_int: 0.999994177
p_ni: 0.000005823
Score: 0.999
Data Source: BioPlex,STRINGDB
RRAGB
Tbio
Novelty: 0.02279777
p_int: 0.999988238
p_ni: 0.000011762
Score: 0.999
Data Source: BioPlex,STRINGDB
RRAGC
Tbio
Novelty: 0.01462756
p_int: 0.999981584
p_ni: 0.000018411
p_wrong: 5e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
BORCS5
Tdark
Novelty: 0.59333419
p_int: 0.999978652
p_ni: 0.000021348
Data Source: BioPlex
BORCS7
Tbio
Novelty: 0.14135922
p_int: 0.999877964
p_ni: 0.000122036
Data Source: BioPlex
BORCS8
Tdark
Novelty: 1.62939642
p_int: 0.999739818
p_ni: 0.000260182
p_wrong: 1e-9
Data Source: BioPlex
BORCS6
Tdark
Novelty: 0.83789033
p_int: 0.99954071
p_ni: 0.000459291
Score: 0.458
Data Source: BioPlex,STRINGDB
PRKAA1
Tclin
Family: Kinase
Novelty: 0.01205826
p_int: 0.998877618
p_ni: 0.001122382
Score: 0.902
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  23.65

PubMed score by year
PubTator Score  10.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer