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Tbio
ELP2
Elongator complex protein 2

Protein Summary
Description
Regulates the ligand-dependent activation of STAT3. Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. The protein encoded by this gene is a core subunit of the elongator complex, a histone acetyltransferase complex that associates with RNA polymerase II. In addition to histone acetylation, the encoded protein effects transcriptional elongation and may help remodel chromatin. [provided by RefSeq, May 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350494
  • ENSP00000316051
  • ENSG00000134759
  • ENST00000351393
  • ENSP00000257191
  • ENST00000358232
  • ENSP00000350967
  • ENST00000423854
  • ENSP00000391202
  • ENST00000442325
  • ENSP00000414851
  • ENST00000539560
  • ENSP00000443555
  • ENST00000542824
  • ENSP00000443800

Symbol
  • STATIP1
  • StIP
  • MRT58
  • SHINC-2
  • STATIP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
transcription factor binding site profile
0.82
transcription factor perturbation
0.8
virus perturbation
0.76
hub protein
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.07   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.07   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (118)
1 – 10 of 118
ELP3
Tbio
Family: Epigenetic
Novelty: 0.0166061
p_int: 0.999986375
p_ni: 0.000013625
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
ZMYM1
Tdark
Novelty: 0.3860445
p_int: 0.993130182
p_ni: 0.006865318
p_wrong: 0.000004499
Data Source: BioPlex
KCMF1
Tbio
Family: Enzyme
Novelty: 0.05485534
p_int: 0.992542946
p_ni: 0.007457054
Data Source: BioPlex
MPG
Tchem
Family: Enzyme
Novelty: 0.00373538
p_int: 0.991228307
p_ni: 0.008771693
Score: 0.534
Data Source: BioPlex,STRINGDB
UBR4
Tbio
Family: Enzyme
Novelty: 0.03924839
p_int: 0.961923768
p_ni: 0.038076232
Data Source: BioPlex
ASAP3
Tbio
Novelty: 0.06898579
p_int: 0.946793711
p_ni: 0.053206289
Score: 0.202
Data Source: BioPlex,STRINGDB
FAM219B
Tdark
Novelty: 5.26378794
p_int: 0.912592399
p_ni: 0.087407601
Score: 0.309
Data Source: BioPlex,STRINGDB
KPTN
Tbio
Novelty: 0.06841936
p_int: 0.890320805
p_ni: 0.109679195
Score: 0.158
Data Source: BioPlex,STRINGDB
STYX
Tbio
Family: Enzyme
Novelty: 0.04754929
p_int: 0.816011635
p_ni: 0.183988365
Data Source: BioPlex
ELP1
Tbio
Novelty: 0.0035777
Score: 0.999
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  36.07

PubMed score by year
PubTator Score  31.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer