Tbio ELP2 Elongator complex protein 2

Protein Summary

Description

Regulates the ligand-dependent activation of STAT3. Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. The protein encoded by this gene is a core subunit of the elongator complex, a histone acetyltransferase complex that associates with RNA polymerase II. In addition to histone acetylation, the encoded protein effects transcriptional elongation and may help remodel chromatin. [provided by RefSeq, May 2016]

Uniprot Accession IDs

• Q6IA86
• A8KAI6
• B4DTG0
• B4DXP0
• E7EP23
• E9PCX0
• Q53GZ0
• Q687Y8
• Q8N5C2
• Q96GV4
• Q96PI7
• Q9H9N0
• Q9NV81
• ELP2

Gene Name

• ELP2

Ensembl ID

• ENST00000350494
• ENSP00000316051
• ENSG00000134759
• ENST00000351393
• ENSP00000257191
• ENST00000358232
• ENSP00000350967
• ENST00000423854
• ENSP00000391202
• ENST00000442325
• ENSP00000414851
• ENST00000539560
• ENSP00000443555
• ENST00000542824
• ENSP00000443800

Symbol

• STATIP1
• StIP
• MRT58
• SHINC-2
• STATIP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.9
transcription factor binding site profile	0.82
transcription factor perturbation	0.8
virus perturbation	0.76
hub protein	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.27   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 112   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.27   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0