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Tbio
NADSYN1
Glutamine-dependent NAD(+) synthetase

Protein Summary
Description
Nicotinamide adenine dinucleotide (NAD) is a coenzyme in metabolic redox reactions, a precursor for several cell signaling molecules, and a substrate for protein posttranslational modifications. NAD synthetase (EC 6.3.5.1) catalyzes the final step in the biosynthesis of NAD from nicotinic acid adenine dinucleotide (NaAD).[supplied by OMIM, Apr 2004]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319023
  • ENSP00000326424
  • ENSG00000172890
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
protein domain
0.73
cell line
0.72
tissue sample
0.61
histone modification site profile
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.7   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.7   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
9
9
10
8.1
100
1
1
0
1.2
70.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
10
8.1
100
0
1.2
70.3
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NAD synthetase 1
VGNC:3098
451395
Macaque
NAD synthetase 1
707652
Mouse
MGI:1926164
78914
Rat
RGD:727801
353255
Dog
NAD synthetase 1
VGNC:43606
483674
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NAD synthetase 1
Macaque
NAD synthetase 1
Mouse
Rat
Dog
NAD synthetase 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6IA69-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (49)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Nicotinate metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Nicotinate metabolism
Gene Ontology Terms (7)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (81)
1 – 10 of 81
TTC9C
Tdark
Novelty: 0.85949913
p_int: 0.999999834
p_ni: 2e-8
p_wrong: 1.46e-7
Data Source: BioPlex
FKBPL
Tbio
Novelty: 0.02054842
p_int: 0.999997595
p_ni: 1.96e-7
p_wrong: 0.000002209
Score: 0.297
Data Source: BioPlex,STRINGDB
UBE2W
Tbio
Novelty: 0.07255713
p_int: 0.999987092
p_ni: 0.000002883
p_wrong: 0.000010025
Data Source: BioPlex
EMC6
Tbio
Novelty: 0.18299013
p_int: 0.999843136
p_ni: 0.00000227
p_wrong: 0.000154594
Data Source: BioPlex
CSGALNACT2
Tbio
Family: Enzyme
Novelty: 0.0770692
p_int: 0.998217404
p_ni: 0.000001484
p_wrong: 0.001781112
Score: 0.161
Data Source: BioPlex,STRINGDB
NMNAT3
Tbio
Family: Enzyme
Novelty: 0.03261313
Score: 0.981
Data Source: STRINGDB
NMNAT2
Tbio
Family: Enzyme
Novelty: 0.01709189
Score: 0.98
Data Source: STRINGDB
NMNAT1
Tbio
Family: Enzyme
Novelty: 0.01110899
Score: 0.977
Data Source: STRINGDB
NADK
Tbio
Family: Kinase
Novelty: 0.02812925
Score: 0.972
Data Source: STRINGDB
NADK2
Tbio
Family: Kinase
Novelty: 0.12395524
Score: 0.937
Data Source: STRINGDB
Publication Statistics
PubMed Score  22.70

PubMed score by year
PubTator Score  31.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer