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Tbio
SIGIRR
Single Ig IL-1-related receptor

Protein Summary
Description
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332725
  • ENSP00000333656
  • ENSG00000185187
  • ENST00000397632
  • ENSP00000380756
  • ENST00000431843
  • ENSP00000403104

Symbol
  • TIR8
  • IL-1R8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
tissue sample
0.7
protein domain
0.58
PubMedID
0.58
biological process
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.35   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 266   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.35   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
1
1
14.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
14.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
single Ig and TIR domain containing
VGNC:12809
743996
Macaque
single Ig and TIR domain containing
100425060
Mouse
MGI:1344402
24058
Rat
RGD:1306732
309106
Dog
single Ig and TIR domain containing
VGNC:46167
100686933
Species
Name
OMA
EggNOG
Inparanoid
Chimp
single Ig and TIR domain containing
Macaque
single Ig and TIR domain containing
Mouse
Rat
Dog
single Ig and TIR domain containing
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6IA17-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-37 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Innate Immune System
Interleukin-1 family signaling
Interleukin-37 signaling
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
HGNC
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (49)
1 – 10 of 49
IL37
Tbio
Novelty: 0.00499186
Score: 0.965
Data Source: Reactome,STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00011808
Score: 0.923
Data Source: STRINGDB
IL18R1
Tbio
Novelty: 0.01634385
Score: 0.917
Data Source: Reactome,STRINGDB
TBK1
Tchem
Family: Kinase
Novelty: 0.00194753
Score: 0.914
Data Source: STRINGDB
IRAK3
Tchem
Family: Kinase
Novelty: 0.01001206
Score: 0.785
Data Source: STRINGDB
MYD88
Tbio
Novelty: 0.00037931
Score: 0.743
Data Source: STRINGDB
TLR4
Tchem
Novelty: 0.00010863
Score: 0.742
Data Source: STRINGDB
TOLLIP
Tbio
Novelty: 0.01032371
Score: 0.741
Data Source: STRINGDB
IRAK1
Tchem
Family: Kinase
Novelty: 0.00170873
Score: 0.722
Data Source: STRINGDB
TRAF6
Tbio
Novelty: 0.00109366
Score: 0.65
Data Source: STRINGDB
Publication Statistics
PubMed Score  88.35

PubMed score by year
PubTator Score  34.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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