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Tbio
ASTL
Astacin-like metalloendopeptidase

Protein Summary
Description
Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342380
  • ENSP00000343674
  • ENSG00000188886

Symbol
  • SAS1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.58
molecular function
0.56
cell line
0.48
transcription factor binding site profile
0.43
cell type or tissue
0.42


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.05   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 45   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.05   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
astacin like metalloendopeptidase
VGNC:48962
741606
Mouse
MGI:3046414
215095
Rat
RGD:1562279
296129
Horse
astacin like metalloendopeptidase
VGNC:15596
100062491
Cow
astacin like metalloendopeptidase
VGNC:26226
511079
Species
Name
OMA
EggNOG
Inparanoid
Chimp
astacin like metalloendopeptidase
Mouse
Rat
Horse
astacin like metalloendopeptidase
Cow
astacin like metalloendopeptidase
Gene Ontology Terms (15)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (38)
1 – 10 of 38
JMJD8
Tbio
Novelty: 0.31175159
p_int: 0.999118002
p_ni: 0.000881994
p_wrong: 4e-9
Score: 0.196
Data Source: BioPlex,STRINGDB
TUBB1
Tclin
Novelty: 0.02806117
p_int: 0.998953019
p_ni: 0.001046981
Score: 0.167
Data Source: BioPlex,STRINGDB
VHL
Tchem
Family: Enzyme
Novelty: 0.00285782
p_int: 0.976643834
p_ni: 0.02305219
p_wrong: 0.000303976
Score: 0.196
Data Source: BioPlex,STRINGDB
LYZL4
Tbio
Family: Enzyme
Novelty: 0.14684776
Score: 0.701
Data Source: STRINGDB
ZP2
Tbio
Novelty: 0.00310166
Score: 0.693
Data Source: STRINGDB
FETUB
Tbio
Novelty: 0.01820964
Score: 0.666
Data Source: STRINGDB
THOP1
Tbio
Family: Enzyme
Novelty: 0.006955
Score: 0.643
Data Source: STRINGDB
TIMP1
Tbio
Family: Enzyme
Novelty: 0.00020986
Score: 0.629
Data Source: STRINGDB
MME
Tclin
Family: Enzyme
Novelty: 0.00019144
Score: 0.628
Data Source: STRINGDB
SPACA3
Tbio
Family: Enzyme
Novelty: 0.04713334
Score: 0.603
Data Source: STRINGDB
Publication Statistics
PubMed Score  48.05

PubMed score by year
PubTator Score  10.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer