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Tdark
ABLIM2
Actin-binding LIM protein 2

Protein Summary
Description
May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341937
  • ENSP00000342813
  • ENSG00000163995
  • ENST00000361581
  • ENSP00000355003
  • ENST00000361737
  • ENSP00000354887
  • ENST00000407564
  • ENSP00000384658
  • ENST00000428004
  • ENSP00000389410
  • ENST00000447017
  • ENSP00000393511
  • ENST00000505872
  • ENSP00000421283
  • ENST00000514025
  • ENSP00000423661

Symbol
  • KIAA1808
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
microRNA
0.68
transcription factor binding site profile
0.66
PubMedID
0.64
biological process
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.09   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.09   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
5
4
5
95.9
3
3
0
1.1
94.8
3
3
0
1.2
91.7
FEV/FEC ratio
1
1
1
54.4
high density lipoprotein cholesterol measurement
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
5
95.9
0
1.1
94.8
0
1.2
91.7
FEV/FEC ratio
1
54.4
high density lipoprotein cholesterol measurement
1
35
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
actin binding LIM protein family member 2
VGNC:2950
750704
Macaque
actin binding LIM protein family member 2
722653
Mouse
MGI:2385758
231148
Rat
RGD:1303094
360958
Dog
actin binding LIM protein family member 2
VGNC:37479
610389
Species
Name
OMA
EggNOG
Inparanoid
Chimp
actin binding LIM protein family member 2
Macaque
actin binding LIM protein family member 2
Mouse
Rat
Dog
actin binding LIM protein family member 2
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q6H8Q1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
DCC mediated attractive signaling
Reactome
Developmental Biology
Reactome
Netrin-1 signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
DCC mediated attractive signaling
Developmental Biology
Netrin-1 signaling
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (45)
1 – 10 of 45
LIN7C
Tbio
Novelty:  0.06778878
p_int:  0.999991841
p_wrong:  0.000008159
Score:  0.296
Data Source:  BioPlex,STRINGDB
ASXL2
Tbio
Family:  Epigenetic
Novelty:  0.04277784
p_int:  0.999813057
p_ni:  0.00011261
p_wrong:  0.000074332
Data Source:  BioPlex
KDM1B
Tbio
Family:  Epigenetic
Novelty:  0.02174039
p_int:  0.993086493
p_ni:  0.00120572
p_wrong:  0.005707786
Data Source:  BioPlex
AFDN
Tbio
Novelty:  0.00372947
p_int:  0.984146603
p_ni:  0.00356681
p_wrong:  0.012286587
Data Source:  BioPlex
DCC
Tbio
Novelty:  0.01273911
Score:  0.936
Data Source:  Reactome,STRINGDB
NTN1
Tbio
Novelty:  0.00183678
Score:  0.936
Data Source:  Reactome,STRINGDB
TRIO
Tbio
Family:  Kinase
Novelty:  0.03113573
Score:  0.925
Data Source:  Reactome,STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.913
Data Source:  Reactome,STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
Score:  0.902
Data Source:  Reactome,STRINGDB
NCK1
Tbio
Novelty:  0.00352084
Score:  0.901
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  4.09

PubMed score by year
PubTator Score  2.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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