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Tbio
RALGAPA1
Ral GTPase-activating protein subunit alpha-1

Protein Summary
Description
Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. This gene encodes a major subunit of the RAL-GTPase activating protein. A similar protein in mouse binds E12, a transcriptional regulator of immunoglobulin genes. The mouse protein also functions in skeletal muscle by binding to the regulatory 14-3-3 proteins upon stimulation with insulin or muscle contraction. A pseudogene of this gene has been identified on chromosome 9. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307138
  • ENSP00000302647
  • ENSG00000174373
  • ENST00000382366
  • ENSP00000371803
  • ENST00000389698
  • ENSP00000374348
  • ENST00000553892
  • ENSP00000451877

Symbol
  • GARNL1
  • KIAA0884
  • TULIP1
  • p240
  • GRIPE
  • GARNL1
  • TULIP1
  • RalGAPalpha1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.79
virus perturbation
0.76
kinase perturbation
0.71
transcription factor
0.69
transcription factor binding site profile
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.14   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.14   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
GFOD1
Tdark
Family:  Enzyme
Novelty:  0.35031766
p_int:  0.999999994
p_ni:  6e-9
Score:  0.681
Data Source:  BioPlex,STRINGDB
NKIRAS2
Tbio
Family:  Enzyme
Novelty:  0.11182522
p_int:  0.999999993
p_ni:  5e-9
p_wrong:  2e-9
Score:  0.874
Data Source:  BioPlex,STRINGDB
DLG3
Tbio
Novelty:  0.01196565
p_int:  0.999308512
p_ni:  0.000691485
p_wrong:  3e-9
Data Source:  BioPlex
AP2M1
Tbio
Novelty:  0.00769368
p_int:  0.99685717
p_ni:  0.00298977
p_wrong:  0.00015306
Data Source:  BioPlex
LRPAP1
Tbio
Novelty:  0.00214194
Score:  0.723
Data Source:  STRINGDB
RANGAP1
Tbio
Family:  Enzyme
Novelty:  0.00917672
Score:  0.647
Data Source:  STRINGDB
RALGAPB
Tbio
Family:  Enzyme
Novelty:  0.31941838
Score:  0.603
Data Source:  STRINGDB
SLC12A8
Tbio
Family:  Transporter
Novelty:  0.06012072
Score:  0.573
Data Source:  STRINGDB
ESYT3
Tbio
Novelty:  0.08038584
Score:  0.553
Data Source:  STRINGDB
AGAP2
Tbio
Family:  Enzyme
Novelty:  0.03487944
Score:  0.538
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (65)
Find Similar Targets
Items per page:
1 – 5 of 65
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Integrated Breast Cancer Pathway
WikiPathways
Integrated Breast Cancer Pathway
WikiPathways
Integrated Breast Cancer Pathway
WikiPathways
Integrated Breast Cancer Pathway
WikiPathways
Integrated Breast Cancer Pathway
Name
Explore in Pharos
Explore in Source
Integrated Breast Cancer Pathway
Integrated Breast Cancer Pathway
Integrated Breast Cancer Pathway
Integrated Breast Cancer Pathway
Integrated Breast Cancer Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
2
2
84.7
hemoglobin measurement
2
2
2
82
red blood cell density measurement
1
1
1
63.4
alkaline phosphatase measurement
1
1
1
53.7
hip circumference
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
84.7
hemoglobin measurement
2
82
red blood cell density measurement
1
63.4
alkaline phosphatase measurement
1
53.7
hip circumference
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Ral GTPase activating protein catalytic alpha subunit 1
VGNC:7032
452864
Macaque
Ral GTPase activating protein catalytic alpha subunit 1
695674
Mouse
MGI:1931050
56784
Horse
Ral GTPase activating protein catalytic alpha subunit 1
VGNC:51652
100058175
Cow
Ral GTPase activating protein catalytic alpha subunit 1
VGNC:33701
618573
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Ral GTPase activating protein catalytic alpha subunit 1
Macaque
Ral GTPase activating protein catalytic alpha subunit 1
Mouse
Horse
Ral GTPase activating protein catalytic alpha subunit 1
Cow
Ral GTPase activating protein catalytic alpha subunit 1
Publication Statistics
PubMed Score 14.14
PubMed score by year
PubTator Score 10.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title