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Tbio
LAIR1
Leukocyte-associated immunoglobulin-like receptor 1

Protein Summary
Description
Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells. The protein encoded by t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348231
  • ENSP00000301193
  • ENSG00000167613
  • ENST00000391742
  • ENSP00000375622
  • ENST00000474878
  • ENSP00000418998
  • ENST00000610549
  • ENSP00000481204
  • ENSG00000276053
  • ENST00000614937
  • ENSP00000479006
  • ENSG00000278154
  • ENST00000614946
  • ENSP00000478853
  • ENSG00000274110
  • ENST00000616612
  • ENSP00000479682
  • ENST00000618434
  • ENSP00000479133
  • ENST00000619717
  • ENSP00000479707
  • ENST00000619817
  • ENSP00000480619
  • ENSG00000276163
  • ENST00000620077
  • ENSP00000482922
  • ENST00000620357
  • ENSP00000479649
  • ENST00000620726
  • ENSP00000478405
  • ENST00000622097
  • ENSP00000480659

Symbol
  • CD305
  • CD305
  • LAIR-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.77
virus perturbation
0.76
tissue sample
0.64
cell line
0.61
kinase perturbation
0.6


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.35   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 700   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.35   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 700   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0