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Tdark
PM20D1
N-fatty-acyl-amino acid synthase/hydrolase PM20D1

Protein Summary
Description
Bidirectional N-fatty-acyl amino acid synthase/hydrolase that regulates the production of N-fatty-acyl amino acids. These metabolites are endogenous chemical uncouplers of mitochondrial respiration. In an UCP1-independent manner, maybe through interaction with mitochondrial transporters, they promote proton leakage into the mitochondrial matrix. Thereby, this secreted protein may indirectly regulate the bodily dissipation of chemical energy as heat through thermogenic respiration.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367136
  • ENSP00000356104
  • ENSG00000162877

Symbol
  • Cps1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.65
microRNA
0.6
cell line
0.59
tissue
0.55
histone modification site profile
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.62   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 25   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.62   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
PDE4DIP
Tbio
Novelty:  0.03414104
p_int:  0.999999104
p_ni:  3.8e-8
p_wrong:  8.58e-7
Data Source:  BioPlex
NPPA
Tchem
Novelty:  0.00046693
p_int:  0.99999829
p_ni:  2.5e-8
p_wrong:  0.000001686
Score:  0.187
Data Source:  BioPlex,STRINGDB
RAB29
Tchem
Family:  Enzyme
Novelty:  0.03751616
Score:  0.804
Data Source:  STRINGDB
NUCKS1
Tbio
Family:  Enzyme
Novelty:  0.02654614
Score:  0.802
Data Source:  STRINGDB
SLC41A1
Tbio
Family:  Transporter
Novelty:  0.01442757
Score:  0.8
Data Source:  STRINGDB
SLC17A3
Tbio
Family:  Transporter
Novelty:  0.04671795
Score:  0.75
Data Source:  STRINGDB
RFC5
Tbio
Novelty:  0.03987481
Score:  0.727
Data Source:  STRINGDB
SLC45A3
Tbio
Family:  Transporter
Novelty:  0.0178929
Score:  0.725
Data Source:  STRINGDB
LGI2
Tbio
Novelty:  0.09195527
Score:  0.714
Data Source:  STRINGDB
CRHBP
Tbio
Novelty:  0.00726484
Score:  0.673
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
2
2
88.7
4
2
0
1.1
77.6
prostate specific antigen measurement
1
2
2
65.7
alkaline phosphatase measurement
2
2
1
6.9
64.2
comparative body size at age 10, self-reported
1
1
1
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
88.7
0
1.1
77.6
prostate specific antigen measurement
2
65.7
alkaline phosphatase measurement
1
6.9
64.2
comparative body size at age 10, self-reported
1
57.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peptidase M20 domain containing 1
VGNC:1460
457674
Macaque
peptidase M20 domain containing 1
696701
Mouse
MGI:2442939
212933
Rat
RGD:1564063
498226
Dog
peptidase M20 domain containing 1
VGNC:44727
106557462
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peptidase M20 domain containing 1
Macaque
peptidase M20 domain containing 1
Mouse
Rat
Dog
peptidase M20 domain containing 1
Publication Statistics
PubMed Score 17.62
PubMed score by year
PubTator Score 4.31
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title