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Tbio
OTUD7B
OTU domain-containing protein 7B

Protein Summary
Description
Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro) ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000581312
  • ENSP00000462729
  • ENSG00000264522

Symbol
  • ZA20D1
  • ZA20D1
  • CEZANNE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
transcription factor binding site profile
0.93
kinase perturbation
0.88
molecular function
0.84
microRNA
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.86   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.86   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
7
11
97.9
body height
7
4
6
5.1
97.7
BMI-adjusted waist circumference
7
4
16
90.8
sex hormone-binding globulin measurement
5
3
5
87.9
body fat distribution
2
1
6
87.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
11
97.9
body height
6
5.1
97.7
BMI-adjusted waist circumference
16
90.8
sex hormone-binding globulin measurement
5
87.9
body fat distribution
6
87.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
OTU deubiquitinase 7B
705774
Mouse
MGI:2654703
229603
Rat
RGD:1308111
310677
Dog
OTU deubiquitinase 7B
VGNC:44191
483178
Horse
OTU deubiquitinase 7B
VGNC:50857
100054396
Species
Name
OMA
EggNOG
Inparanoid
Macaque
OTU deubiquitinase 7B
Mouse
Rat
Dog
OTU deubiquitinase 7B
Horse
OTU deubiquitinase 7B
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q6GQQ9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (105)
Death Receptor Signalling (R-HSA-73887)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Death Receptor Signalling
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Ovarian tumor domain proteases
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Death Receptor Signalling
Deubiquitination
Metabolism of proteins
Ovarian tumor domain proteases
Post-translational protein modification
Gene Ontology Terms (21)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (123)
1 – 10 of 123
HIF1AN
Tbio
Novelty:  0.00861018
p_int:  0.999999998
p_ni:  2e-9
Score:  0.253
Data Source:  BioPlex,STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.994
Data Source:  STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.994
Data Source:  STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.992
Data Source:  STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.991
Data Source:  STRINGDB
TRAF6
Tbio
Novelty:  0.00109366
Score:  0.962
Data Source:  Reactome,STRINGDB
TAB2
Tbio
Family:  Enzyme
Novelty:  0.00635786
Score:  0.949
Data Source:  STRINGDB
RNF31
Tbio
Family:  Enzyme
Novelty:  0.01394304
Score:  0.942
Data Source:  STRINGDB
IKBKG
Tbio
Family:  Kinase
Novelty:  0.0006149
Score:  0.942
Data Source:  STRINGDB
RIPK1
Tchem
Family:  Kinase
Novelty:  0.00230565
Score:  0.941
Data Source:  STRINGDB
Publication Statistics
PubMed Score  85.86

PubMed score by year
PubTator Score  18.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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