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Tdark
ITPRIPL1
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361124
  • ENSP00000355121
  • ENSG00000198885
  • ENST00000439118
  • ENSP00000389308
  • ENST00000536814
  • ENSP00000439566

Symbol
  • KIAA1754L
  • KIAA1754L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.65
transcription factor
0.61
tissue sample
0.55
tissue
0.52
cell line
0.49


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.61   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.61   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
1
21.5
diastolic blood pressure
1
1
1
15.8
eosinophil count
1
1
1
9.8
eosinophil percentage of leukocytes
1
1
1
5.7
calcium measurement
1
1
1
4.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
21.5
diastolic blood pressure
1
15.8
eosinophil count
1
9.8
eosinophil percentage of leukocytes
1
5.7
calcium measurement
1
4.9
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ITPRIP like 1
VGNC:49084
459415
Macaque
ITPRIP like 1
705560
Mouse
MGI:1920588
73338
Rat
RGD:1564158
499885
Dog
ITPRIP like 1
VGNC:42160
611643
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ITPRIP like 1
Macaque
ITPRIP like 1
Mouse
Rat
Dog
ITPRIP like 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6GPH6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (2)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (36)
1 – 10 of 36
HTR2C
Tclin
Family:  GPCR
Novelty:  0.00074287
p_int:  0.998429732
p_ni:  0.001570268
Data Source:  BioPlex
GPR183
Tchem
Family:  GPCR
Novelty:  0.02005679
p_int:  0.997690308
p_ni:  0.002309692
Score:  0.189
Data Source:  BioPlex,STRINGDB
CD226
Tbio
Novelty:  0.00374102
p_int:  0.966451696
p_ni:  0.033547654
p_wrong:  6.5e-7
Data Source:  BioPlex
SPINT2
Tbio
Family:  Enzyme
Novelty:  0.0046602
p_int:  0.854785145
p_ni:  0.145214853
p_wrong:  2e-9
Data Source:  BioPlex
ADCY9
Tbio
Family:  Enzyme
Novelty:  0.00744116
p_int:  0.784059802
p_ni:  0.211066034
p_wrong:  0.004874164
Data Source:  BioPlex
NCAPH
Tbio
Novelty:  0.01598076
Score:  0.8
Data Source:  STRINGDB
CIAO1
Tbio
Novelty:  0.03999673
Score:  0.711
Data Source:  STRINGDB
FAHD2B
Tdark
Family:  Enzyme
Novelty:  1.47557507
Score:  0.671
Data Source:  STRINGDB
FAM178B
Tdark
Novelty:  3.72734051
Score:  0.669
Data Source:  STRINGDB
ANKRD39
Tdark
Novelty:  8.68843298
Score:  0.644
Data Source:  STRINGDB
Publication Statistics
PubMed Score  0.61

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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