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Tbio
XAF1
XIAP-associated factor 1

Protein Summary
Description
Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondria, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells. This gene encodes a protein which bind ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346752
  • ENSP00000341029
  • ENSG00000132530
  • ENST00000361842
  • ENSP00000354822
  • ENST00000571673
  • ENSP00000461196
  • ENST00000574962
  • ENSP00000458229

Symbol
  • BIRC4BP
  • XIAPAF1
  • BIRC4BP
  • XIAPAF1
  • HSXIAPAF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
gene perturbation
0.95
cell type or tissue
0.66
PubMedID
0.65
biological term
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.83   (req: < 5)
Gene RIFs: 64   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.83   (req: >= 5)
Gene RIFs: 64   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon alpha/beta signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon alpha/beta signaling
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (165)
1 – 10 of 165
TSGA10IP
Tdark
p_int: 0.980241606
p_ni: 0.006906127
p_wrong: 0.012852267
Data Source: BioPlex
RSAD2
Tbio
Novelty: 0.00786985
Score: 0.99
Data Source: STRINGDB
MX1
Tbio
Novelty: 0.00081841
Score: 0.989
Data Source: STRINGDB
IFIT3
Tbio
Novelty: 0.00899003
Score: 0.988
Data Source: STRINGDB
OAS2
Tbio
Family: Enzyme
Novelty: 0.03283444
Score: 0.987
Data Source: STRINGDB
IFIT1
Tbio
Novelty: 0.00862855
Score: 0.987
Data Source: STRINGDB
ISG15
Tbio
Novelty: 0.00256125
Score: 0.986
Data Source: STRINGDB
OASL
Tbio
Family: Enzyme
Novelty: 0.02020019
Score: 0.984
Data Source: STRINGDB
OAS3
Tbio
Family: Enzyme
Novelty: 0.04260345
Score: 0.984
Data Source: STRINGDB
IFI6
Tbio
Novelty: 0.04401105
Score: 0.984
Data Source: STRINGDB
Publication Statistics
PubMed Score  76.83

PubMed score by year
PubTator Score  68.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer