You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
XAF1
XIAP-associated factor 1

Protein Summary
Description
Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondria, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells. This gene encodes a protein which bind ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346752
  • ENSP00000341029
  • ENSG00000132530
  • ENST00000361842
  • ENSP00000354822
  • ENST00000571673
  • ENSP00000461196
  • ENST00000574962
  • ENSP00000458229

Symbol
  • BIRC4BP
  • XIAPAF1
  • BIRC4BP
  • XIAPAF1
  • HSXIAPAF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
gene perturbation
0.95
cell type or tissue
0.66
PubMedID
0.65
biological term
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.14   (req: < 5)
Gene RIFs: 64   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.14   (req: >= 5)
Gene RIFs: 64   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
2
3
3
85.6
amino acid measurement
1
1
1
69.5
protein measurement
1
1
1
69.5
calcium measurement
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
85.6
amino acid measurement
1
69.5
protein measurement
1
69.5
calcium measurement
1
39.6
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
XIAP associated factor 1
VGNC:9789
455244
Macaque
XIAP associated factor 1
713425
Mouse
MGI:3772572
327959
Rat
RGD:1585988
679600
Dog
XIAP associated factor 1
VGNC:48446
606957
Species
Name
OMA
EggNOG
Inparanoid
Chimp
XIAP associated factor 1
Macaque
XIAP associated factor 1
Mouse
Rat
Dog
XIAP associated factor 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q6GPH4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon alpha/beta signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon alpha/beta signaling
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (165)
1 – 10 of 165
TSGA10IP
Tdark
Novelty:  20.75428866
p_int:  0.980241606
p_ni:  0.006906127
p_wrong:  0.012852267
Data Source:  BioPlex
RSAD2
Tbio
Novelty:  0.0056473
Score:  0.99
Data Source:  STRINGDB
MX1
Tbio
Novelty:  0.00072554
Score:  0.989
Data Source:  STRINGDB
IFIT3
Tbio
Novelty:  0.00568113
Score:  0.988
Data Source:  STRINGDB
OAS2
Tbio
Family:  Enzyme
Novelty:  0.01673393
Score:  0.987
Data Source:  STRINGDB
IFIT1
Tbio
Novelty:  0.00562299
Score:  0.987
Data Source:  STRINGDB
ISG15
Tbio
Novelty:  0.00203781
Score:  0.986
Data Source:  STRINGDB
OASL
Tbio
Family:  Enzyme
Novelty:  0.01502223
Score:  0.984
Data Source:  STRINGDB
OAS3
Tbio
Family:  Enzyme
Novelty:  0.02422229
Score:  0.984
Data Source:  STRINGDB
IFI6
Tbio
Novelty:  0.02590679
Score:  0.984
Data Source:  STRINGDB
Publication Statistics
PubMed Score  87.14

PubMed score by year
PubTator Score  68.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer