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Tchem
FAAH2
Fatty-acid amide hydrolase 2

Protein Summary
Description
Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates. This gene encodes a fatty acid amide hydrolase that shares a conserved protein motif with the amidase signature family of enzymes. The encoded enzyme is able to catalyze the hydrolysis of a broad range of bioactive lipids, including those from the three main classes of fatty acid amides; N-acylethanolamines, fatty acid primary amides and N-acyl amino acids. This enzyme has a preference for monounsaturated acyl chains as a substrate. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374900
  • ENSP00000364035
  • ENSG00000165591

Symbol
  • AMDD
  • AMDD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
cell type or tissue
0.62
tissue sample
0.5
cell line
0.45
metabolite
0.45


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.11   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.11   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (38)
GATB
Tbio
Family:  Enzyme
Novelty:  0.01269151
Score:  0.854
Data Source:  STRINGDB
PEPD
Tchem
Family:  Enzyme
Novelty:  0.00141261
Score:  0.804
Data Source:  STRINGDB
NAPEPLD
Tbio
Family:  Enzyme
Novelty:  0.00755191
Score:  0.764
Data Source:  STRINGDB
NAAA
Tchem
Family:  Enzyme
Novelty:  0.00368876
Score:  0.76
Data Source:  STRINGDB
STK16
Tchem
Family:  Kinase
Novelty:  0.01499094
Score:  0.754
Data Source:  STRINGDB
ABHD4
Tbio
Family:  Enzyme
Novelty:  0.1068785
Score:  0.743
Data Source:  STRINGDB
GPKOW
Tbio
Novelty:  0.14830491
Score:  0.732
Data Source:  STRINGDB
GDE1
Tbio
Family:  Enzyme
Novelty:  0.05854843
Score:  0.726
Data Source:  STRINGDB
EPRS
Tchem
Family:  Enzyme
Novelty:  0.00084896
Score:  0.72
Data Source:  STRINGDB
RGN
Tbio
Novelty:  0.00210816
Score:  0.685
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Fatty acid metabolism
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
2
3
81.6
body height
1
1
1
79.5
hemoglobin measurement
1
1
1
72.6
reticulocyte count
2
1
2
39.6
age at menarche
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
81.6
body height
1
79.5
hemoglobin measurement
1
72.6
reticulocyte count
2
39.6
age at menarche
1
33.1
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fatty acid amide hydrolase 2
VGNC:1388
465664
Macaque
fatty acid amide hydrolase 2
705856
Opossum
fatty acid amide hydrolase 2
100024089
Anole lizard
fatty acid amide hydrolase 2
100564222
Xenopus
fatty acid amide hydrolase 2 [Source:Xenbase;Acc:XB-GENE-6036595]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fatty acid amide hydrolase 2
Macaque
fatty acid amide hydrolase 2
Opossum
fatty acid amide hydrolase 2
Anole lizard
fatty acid amide hydrolase 2
Xenopus
fatty acid amide hydrolase 2 [Source:Xenbase;Acc:XB-GENE-6036595]
Publication Statistics
PubMed Score 14.11
PubMed score by year
PubTator Score 9.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title