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Tbio
TTLL5
Tubulin polyglutamylase TTLL5

Protein Summary
Description
Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction (PubMed:17116691, PubMed:22493317). This gene encodes a member of the tubulin tyrosine ligase like protein family. This protein interacts with two glucocorticoid receptor coactivators, transcriptional intermediary factor 2 and steroid receptor coactivator 1. This protein may function as a coregulator of glucocorticoid receptor mediated gene induction and repression. This protein may also function as an alpha tubulin polyglutamylase.[provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286650
  • ENSP00000286650
  • ENSG00000119685
  • ENST00000298832
  • ENSP00000298832
  • ENST00000556893
  • ENSP00000452524

Symbol
  • KIAA0998
  • STAMP
  • STAMP
  • CORD19
  • KIAA0998
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
disease perturbation
0.83
kinase perturbation
0.76
virus perturbation
0.76
transcription factor binding site profile
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.89   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 47   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.89   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 47   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.1
69.3
body height
1
1
1
42.3
1
1
0
1.2
24.5
1
1
0
1.1
1.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
69.3
body height
1
42.3
0
1.2
24.5
0
1.1
1.8
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tubulin tyrosine ligase like 5
VGNC:3292
453052
Mouse
MGI:2443657
320244
Dog
tubulin tyrosine ligase like 5
VGNC:47976
480394
Horse
tubulin tyrosine ligase like 5
VGNC:24647
100051705
Cow
tubulin tyrosine ligase like 5
VGNC:36493
538422
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tubulin tyrosine ligase like 5
Mouse
Dog
tubulin tyrosine ligase like 5
Horse
tubulin tyrosine ligase like 5
Cow
tubulin tyrosine ligase like 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6EMB2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Carboxyterminal post-translational modifications of tubulin
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Carboxyterminal post-translational modifications of tubulin
Metabolism of proteins
Post-translational protein modification
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (79)
1 – 10 of 79
TSGA10IP
Tdark
Novelty:  20.75428866
p_int:  0.999998489
p_ni:  0.000001511
Data Source:  BioPlex
VWCE
Tbio
Novelty:  0.09328341
p_int:  0.999987862
p_ni:  0.000012138
Score:  0.186
Data Source:  BioPlex,STRINGDB
TTC25
Tdark
Novelty:  0.23064129
p_int:  0.997217073
p_ni:  0.001258906
p_wrong:  0.001524021
Score:  0.339
Data Source:  BioPlex,STRINGDB
CSRNP1
Tbio
Novelty:  0.10538864
p_int:  0.994298451
p_ni:  0.004444647
p_wrong:  0.001256902
Data Source:  BioPlex
CACNG5
Tdark
Family:  IC
Novelty:  0.52705448
p_int:  0.988568344
p_ni:  0.010414087
p_wrong:  0.001017569
Score:  0.161
Data Source:  BioPlex,STRINGDB
NCOA2
Tbio
Novelty:  0.00510052
Score:  0.897
Data Source:  STRINGDB
WDR90
Tdark
Novelty:  0.39919716
Score:  0.749
Data Source:  STRINGDB
CCDC61
Tdark
Novelty:  0.78730217
Score:  0.729
Data Source:  STRINGDB
KIAA1328
Tdark
Novelty:  0.81945714
Score:  0.717
Data Source:  STRINGDB
PIBF1
Tbio
Novelty:  0.0454209
Score:  0.708
Data Source:  STRINGDB
Publication Statistics
PubMed Score  8.89

PubMed score by year
PubTator Score  49.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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