Tbio GTF2IRD2B General transcription factor II-I repeat domain-containing protein 2B

Protein Summary

Description

This gene encodes a glycosylated phosphoprotein with a leucine zipper motif, two helix-loop-helix motifs (I repeats) that are similar to domains found in the TFII-I family of transcription factors, one CHARLIE8 transposable element-like sequence, and a BED zinc finger. This gene lies within a region that is deleted in Williams-Beuren syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q6EKJ0
• B2RNE9
• Q69GU6
• Q8N979
• Q9H739
• GTF2I repeat domain-containing protein 2B

Gene Name

• GTF2IRD2B

Ensembl ID

• ENST00000418185
• ENSP00000411454
• ENSG00000174428
• ENST00000472837
• ENSP00000480524

Symbol

• GTF2IRD2
• GTF2IRD2A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	0.76
cell type or tissue	0.74
tissue sample	0.52
cell line	0.48
cellular component	0.42

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.4   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 64   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.4   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0