Pharos : Target Details

Tbio

Protein Summary

Description

This gene encodes a subunit of a specific form of RNA polymerase II termed Pol II(G). The encoded protein may act as a negative regulator of transcriptional activation by the Mediator complex. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 4. Readthrough transcription between this gene and the neighboring upstream gene MYZAP (myocardial zonula adherens protein) is represented with GeneID 145781. [provided by RefSeq, Oct 2013]

Uniprot Accession IDs

Gene Name

POLR2M

Ensembl ID

ENST00000649091
ENSP00000497820
ENSG00000255529

Symbol

GRINL1A
GCOM1
Gdown
Gdown1
GRINL1A

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0

biological term	0

cell line	0

cell type or tissue	0

cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.04 (req: < 5)

View Publications

Gene RIFs: 7 (req: <= 3)

View Gene RIFs

Antibodies: 0 (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.04 (req: >= 5)

Gene RIFs: 7 (req: > 3)

Antibodies: 0 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (3)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (53)

Explore Interacting Targets

1 – 10 of 53

See Interactions on String-DB

POLR2D

Tdark

Family: Enzyme

Novelty: 0.11021614

p_int: 1

Score: 0.858

Data Source: BioPlex,STRINGDB

RPRD1B

Tbio

Novelty: 0.0444394

p_int: 0.999999999

p_ni: 1e-9

Score: 0.827

Data Source: BioPlex,STRINGDB

POLR2G

Tbio

Family: Enzyme

Novelty: 0.01235379

p_int: 0.999999997

p_ni: 3e-9

Score: 0.851

Data Source: BioPlex,STRINGDB

GPN3

Tbio

Family: Enzyme

Novelty: 0.13817794

p_int: 0.999999963

p_ni: 3.7e-8

Score: 0.594

Data Source: BioPlex,STRINGDB

RECQL5

Tbio

Family: Enzyme

Novelty: 0.01558497

p_int: 0.999995024

p_ni: 0.000004974

p_wrong: 2e-9

Score: 0.855

Data Source: BioPlex,STRINGDB

CD19

Tclin

Novelty: 0.0001816

p_int: 0.999972195

p_ni: 0.000027805

Score: 0.169

Data Source: BioPlex,STRINGDB

BIN1

Tbio

Novelty: 0.00312612

p_int: 0.999970042

p_ni: 0.000029957

p_wrong: 1e-9

Data Source: BioPlex

RPRD1A

Tbio

Novelty: 0.13521196

p_int: 0.999860672

p_ni: 0.000139327

p_wrong: 1e-9

Score: 0.767

Data Source: BioPlex,STRINGDB

RPAP2

Tbio

Family: Enzyme

Novelty: 0.03383659

p_int: 0.999850099

p_ni: 0.000149901

Score: 0.809

Data Source: BioPlex,STRINGDB

PIH1D1

Tbio

Novelty: 0.10737369

p_int: 0.999845001

p_ni: 0.000154999

Score: 0.766

Data Source: BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (0)

No GO Terms found

Disease Associations (null)

No disease associations found

GWAS Traits (4)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
atrial fibrillation	EFO_0000275	1	1	0	1.4	42.3

atrial fibrillation	EFO_0000275	1	1	0	1.4	42.3

exercise test	EFO_0004328	1	1	0	26.1	6.7

exercise test	EFO_0004328	1	1	0	26.1	6.7

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
atrial fibrillation	EFO_0000275	0	1.4	42.3

atrial fibrillation	EFO_0000275	0	1.4	42.3

exercise test	EFO_0004328	0	26.1	6.7

exercise test	EFO_0004328	0	26.1	6.7

Beta Count

Odds Ratio

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IDG Resources

No IDG generated resources found

Orthologs (6)

1 – 5 of 6

Species	Name	Source ID	Gene ID
Mouse	polymerase (RNA) II (DNA directed) polypeptide M	MGI:107282	28015

Dog	RNA polymerase II subunit M		478318

Cow	RNA polymerase II subunit M		100125877

Pig	RNA polymerase II subunit M		102160778

Anole lizard	RNA polymerase II subunit M [Source:HGNC Symbol;Acc:HGNC:14862]

Species	Name	OMA	EggNOG	Inparanoid
Mouse	polymerase (RNA) II (DNA directed) polypeptide M

Dog	RNA polymerase II subunit M

Cow	RNA polymerase II subunit M

Pig	RNA polymerase II subunit M

Anole lizard	RNA polymerase II subunit M [Source:HGNC Symbol;Acc:HGNC:14862]

Publication Statistics

PubMed Score 17.04

PubMed score by year

PubTator Score 11.17

PubTator score by year

Related Publications

Text Mined References (27)

GeneRif Annotations (7)

Items per page:

0 of 0

PMID	Year	Title

No Header	No Header
Alternative splicing

Complete proteome

Polymorphism

Reference proteome