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Tbio
Q6EEV4
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

Protein Summary
Description
This gene encodes a subunit of a specific form of RNA polymerase II termed Pol II(G). The encoded protein may act as a negative regulator of transcriptional activation by the Mediator complex. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 4. Readthrough transcription between this gene and the neighboring upstream gene MYZAP (myocardial zonula adherens protein) is represented with GeneID 145781. [provided by RefSeq, Oct 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000649091
  • ENSP00000497820
  • ENSG00000255529

Symbol
  • GRINL1A
  • GCOM1
  • Gdown
  • Gdown1
  • GRINL1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.04   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.04   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
POLR2D
Tdark
Family:  Enzyme
Novelty:  0.11021614
p_int:  1
Score:  0.858
Data Source:  BioPlex,STRINGDB
RPRD1B
Tbio
Novelty:  0.0444394
p_int:  0.999999999
p_ni:  1e-9
Score:  0.827
Data Source:  BioPlex,STRINGDB
POLR2G
Tbio
Family:  Enzyme
Novelty:  0.01235379
p_int:  0.999999997
p_ni:  3e-9
Score:  0.851
Data Source:  BioPlex,STRINGDB
GPN3
Tbio
Family:  Enzyme
Novelty:  0.13817794
p_int:  0.999999963
p_ni:  3.7e-8
Score:  0.594
Data Source:  BioPlex,STRINGDB
RECQL5
Tbio
Family:  Enzyme
Novelty:  0.01558497
p_int:  0.999995024
p_ni:  0.000004974
p_wrong:  2e-9
Score:  0.855
Data Source:  BioPlex,STRINGDB
CD19
Tclin
Novelty:  0.0001816
p_int:  0.999972195
p_ni:  0.000027805
Score:  0.169
Data Source:  BioPlex,STRINGDB
BIN1
Tbio
Novelty:  0.00312612
p_int:  0.999970042
p_ni:  0.000029957
p_wrong:  1e-9
Data Source:  BioPlex
RPRD1A
Tbio
Novelty:  0.13521196
p_int:  0.999860672
p_ni:  0.000139327
p_wrong:  1e-9
Score:  0.767
Data Source:  BioPlex,STRINGDB
RPAP2
Tbio
Family:  Enzyme
Novelty:  0.03383659
p_int:  0.999850099
p_ni:  0.000149901
Score:  0.809
Data Source:  BioPlex,STRINGDB
PIH1D1
Tbio
Novelty:  0.10737369
p_int:  0.999845001
p_ni:  0.000154999
Score:  0.766
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.4
42.3
1
1
0
1.4
42.3
exercise test
1
1
0
26.1
6.7
exercise test
1
1
0
26.1
6.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
42.3
0
1.4
42.3
exercise test
0
26.1
6.7
exercise test
0
26.1
6.7
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:107282
28015
Dog
RNA polymerase II subunit M
478318
Cow
RNA polymerase II subunit M
100125877
Pig
RNA polymerase II subunit M
102160778
Anole lizard
RNA polymerase II subunit M [Source:HGNC Symbol;Acc:HGNC:14862]
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
RNA polymerase II subunit M
Cow
RNA polymerase II subunit M
Pig
RNA polymerase II subunit M
Anole lizard
RNA polymerase II subunit M [Source:HGNC Symbol;Acc:HGNC:14862]
Publication Statistics
PubMed Score 17.04
PubMed score by year
PubTator Score 11.17
PubTator score by year
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Related Publications
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PMID
Year
Title