Tbio AWAT2 Acyl-CoA wax alcohol acyltransferase 2

Protein Summary

Description

Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has no activity using decyl alcohol and significantly prefers the C16 and C18 alcohols. May also have 2-acylglycerol O-acyltransferase (MGAT) and acyl-CoA:retinol acyltransferase (ARAT) activities, to catalyze the synthesis of diacylglycerols and retinyl esters; however this activity is unclear in vivo. This gene encodes an enzyme belonging to the diacylglycerol acyltransferase family. This enzyme produces wax esters by the esterification of long chain (or wax) alcohols with acyl-CoA-derived fatty acids. It functions in lipid metabolism in the skin, mostly in undifferentiated peripheral sebocytes. This enzyme may also have acyl-CoA:retinol acyltransferase activities, where it catalyzes the synthesis of diacylglycerols and retinyl esters. [provided by RefSeq, May 2010]

Uniprot Accession IDs

• Q6E213
• Q6IEE3
• Q6P437

Gene Name

• AWAT2

Ensembl ID

• ENST00000276101
• ENSP00000421172
• ENSG00000147160

Symbol

• DC4
• DGAT2L4
• MFAT
• WS
• WS
• DC4
• ARAT
• MFAT
• DGAT2L4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
metabolite	0.83
cell type or tissue	0.54
microRNA	0.47
tissue	0.42
cell line	0.41

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / Acyl-coa Wax Alcohol Acyltransferase 2

DTO Classes

Protein / Enzyme / Transferase / Acyltransferase / Acyl-coa Wax Alcohol Acyltransferase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 173.83   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 95   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 173.83   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0