Protein Summary
May act as a soluble regulator of keratinocyte differentiation. This gene is upregulated in inflammatory diseases, and it was first observed as expressed in the differentiated layers of skin. The most interesting aspect of this gene is the differential use of promoters and terminators to generate isoforms with unique cellular distributions and domain components. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]
- ENST00000339686
- ENSP00000342012
- ENSG00000161249
- ENST00000408915
- ENSP00000386225
- ENST00000414866
- ENSP00000392222
- ENST00000418261
- ENSP00000414743
- ENST00000419602
- ENSP00000391036
- ENST00000424570
- ENSP00000388404
- ENST00000429837
- ENSP00000405503
- ENST00000447113
- ENSP00000394908
- ENST00000451297
- ENSP00000409513
- ENST00000472252
- ENSP00000473341
- ENST00000492341
- ENSP00000474419
- UNQ729
- ZD52F10
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 1 | ||
PubMedID | 0.71 | ||
transcription factor perturbation | 0.68 | ||
transcription factor | 0.61 | ||
cell type or tissue | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.43 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 93 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.43 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 93 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (10)
RBM24
Novelty: 0.04562076
p_int: 0.999491475
p_ni: 0.000042301
p_wrong: 0.000466223
Score: 0.214
Data Source: BioPlex,STRINGDB
ZSCAN12
Family: TF
Novelty: 0.33578207
p_int: 0.999179702
p_ni: 0.000818558
p_wrong: 0.00000174
Score: 0.188
Data Source: BioPlex,STRINGDB
FCF1
Novelty: 0.04202976
p_int: 0.994736674
p_ni: 0.005261506
p_wrong: 0.000001821
Score: 0.179
Data Source: BioPlex,STRINGDB
SSH2
Family: Enzyme
Novelty: 0.05112042
p_int: 0.784454353
p_ni: 0.000335904
p_wrong: 0.215209743
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (2)
Components (1)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
platelet count | 3 | 3 | 3 | 86.2 | |||||
hemoglobin measurement | 3 | 3 | 3 | 76.8 | |||||
serum albumin measurement | 1 | 1 | 1 | 69.8 | |||||
red blood cell distribution width | 2 | 2 | 2 | 67.1 | |||||
serum alanine aminotransferase measurement | 2 | 1 | 1 | 6.9 | 66.8 | ||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
platelet count | 3 | 86.2 | |||||
hemoglobin measurement | 3 | 76.8 | |||||
serum albumin measurement | 1 | 69.8 | |||||
red blood cell distribution width | 2 | 67.1 | |||||
serum alanine aminotransferase measurement | 1 | 6.9 | 66.8 | ||||
Find similar targets by:
IDG Resources
Orthologs (5)
1 – 5 of 5
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | dermokine | 718709 | ||||||
Mouse | MGI:1920962 | 73712 | ||||||
Rat | RGD:1561521 | 361548 | ||||||
Dog | dermokine | VGNC:40000 | 476484 | |||||
Cow | dermokine | VGNC:28107 | 618159 | |||||
Publication Statistics
PubMed Score 12.43
PubMed score by year
PubTator Score 2.51
PubTator score by year
Related Publications
Text Mined References (18)
GeneRif Annotations (7)
Items per page:
0 of 0
PMID | Year | Title |
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