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Tchem
GPR139
Probable G-protein coupled receptor 139

Protein Summary
Description
Orphan receptor. Seems to act through a G(q/11)-mediated pathway. This gene encodes a member of the rhodopsin family of G-protein-coupled receptors. The encoded protein is almost exclusively expressed in the central nervous system. L-tryptophan and L-phenylalanine may act as the physiologic ligands of the encoded protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000570682
  • ENSP00000458791
  • ENSG00000180269

Symbol
  • GPRG1
  • PGR3
  • PGR3
  • GPRg1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.61
cell line
0.59
molecular function
0.49
PubMedID
0.49
phenotype
0.37


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.08   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.08   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 20
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
1
4
96.1
birth weight
1
1
1
21.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
96.1
birth weight
1
21.7
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2685341
209776
Rat
RGD:1311729
293545
Dog
G protein-coupled receptor 139
VGNC:41400
489988
Horse
G protein-coupled receptor 139
VGNC:18512
100049812
Cow
G protein-coupled receptor 139
VGNC:29553
540680
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
G protein-coupled receptor 139
Horse
G protein-coupled receptor 139
Cow
G protein-coupled receptor 139
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6DWJ6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (31)
1 – 10 of 31
GPR146
Tbio
Family: GPCR
Novelty: 0.10269429
Score: 0.788
Data Source: STRINGDB
GPR141
Tdark
Family: GPCR
Novelty: 0.30711523
Score: 0.759
Data Source: STRINGDB
GPR148
Tbio
Family: GPCR
Novelty: 0.019374
Score: 0.737
Data Source: STRINGDB
ADGRF2
Tdark
Family: GPCR
Novelty: 0.35622722
Score: 0.726
Data Source: STRINGDB
ADGRF1
Tbio
Family: GPCR
Novelty: 0.13200232
Score: 0.716
Data Source: STRINGDB
NPSR1
Tchem
Family: GPCR
Novelty: 0.00562139
Score: 0.713
Data Source: STRINGDB
GPR83
Tchem
Family: GPCR
Novelty: 0.03554942
Score: 0.71
Data Source: STRINGDB
GPR162
Tbio
Family: GPCR
Novelty: 0.14938549
Score: 0.665
Data Source: STRINGDB
GPR153
Tdark
Family: GPCR
Novelty: 0.44419008
Score: 0.635
Data Source: STRINGDB
GPR12
Tbio
Family: GPCR
Novelty: 0.04712379
Score: 0.625
Data Source: STRINGDB
Publication Statistics
PubMed Score  30.08

PubMed score by year
PubTator Score  14.9

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer