You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
CDC42BPG
Serine/threonine-protein kinase MRCK gamma

Protein Summary
Description
May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342711
  • ENSP00000345133
  • ENSG00000171219

Symbol
  • DMPK2
  • DMPK2
  • MRCKG
  • HSMDPKIN
  • KAPPA-200
  • MRCKgamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.95
metabolite
0.82
interacting protein
0.62
kinase perturbation
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.97   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 31   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.97   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0