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Tbio
CDC42BPG
Serine/threonine-protein kinase MRCK gamma

Protein Summary
Description
May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342711
  • ENSP00000345133
  • ENSG00000171219

Symbol
  • DMPK2
  • DMPK2
  • MRCKG
  • HSMDPKIN
  • KAPPA-200
  • MRCKgamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.95
metabolite
0.82
interacting protein
0.62
kinase perturbation
0.6


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.41   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 31   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.41   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
uric acid measurement
1
1
0
13.8
34.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
uric acid measurement
0
13.8
34.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CDC42 binding protein kinase gamma
VGNC:6483
742988
Macaque
CDC42 binding protein kinase gamma
722039
Mouse
MGI:2652845
240505
Rat
RGD:1307260
293693
Dog
CDC42 binding protein kinase gamma
VGNC:38999
483757
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CDC42 binding protein kinase gamma
Macaque
CDC42 binding protein kinase gamma
Mouse
Rat
Dog
CDC42 binding protein kinase gamma
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6DT37-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (35)
1 – 10 of 35
FAM167A
Tbio
Novelty: 0.05232679
p_int: 0.999999921
p_ni: 7.8e-8
Score: 0.241
Data Source: BioPlex,STRINGDB
ATG2A
Tbio
Novelty: 0.06244231
Score: 0.72
Data Source: STRINGDB
RFTN1
Tbio
Novelty: 0.08295743
Score: 0.713
Data Source: STRINGDB
ACOT11
Tbio
Family: Enzyme
Novelty: 0.0400726
Score: 0.71
Data Source: STRINGDB
SLC2A9
Tbio
Family: Transporter
Novelty: 0.00683926
Score: 0.638
Data Source: STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.603
Data Source: STRINGDB
ACAD11
Tbio
Family: Enzyme
Novelty: 0.22908145
Score: 0.575
Data Source: STRINGDB
RAP2A
Tbio
Family: Enzyme
Novelty: 0.00541101
Score: 0.569
Data Source: STRINGDB
ATG2B
Tbio
Novelty: 0.04963717
Score: 0.561
Data Source: STRINGDB
TUBD1
Tbio
Novelty: 0.03591414
Score: 0.518
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.41

PubMed score by year
PubTator Score  3.65

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer