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Tbio
IQSEC1
IQ motif and SEC7 domain-containing protein 1

Protein Summary
Description
Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273221
  • ENSP00000273221
  • ENSG00000144711

Symbol
  • ARFGEP100
  • BRAG2
  • KIAA0763
  • BRAG2
  • GEP100
  • ARFGEP100
  • ARF-GEP100
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
microRNA
0.8
interacting protein
0.75
protein domain
0.73
drug perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.06   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.06   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
INSYN2
Tdark
Novelty:  2.55244594
p_int:  0.998404866
p_ni:  0.001595133
p_wrong:  1e-9
Score:  0.175
Data Source:  BioPlex,STRINGDB
APBA2
Tbio
Novelty:  0.01654185
p_int:  0.997037706
p_ni:  0.002962294
Score:  0.201
Data Source:  BioPlex,STRINGDB
MLLT6
Tdark
Family:  Epigenetic
Novelty:  0.03728427
p_int:  0.970208851
p_ni:  0.029791149
Score:  0.205
Data Source:  BioPlex,STRINGDB
SKP2
Tbio
Family:  Enzyme
Novelty:  0.00182658
p_int:  0.955772917
p_ni:  0.044227083
p_wrong:  1e-9
Data Source:  BioPlex
P4HA2
Tbio
Family:  Enzyme
Novelty:  0.02097718
p_int:  0.894554226
p_ni:  0.105445771
p_wrong:  4e-9
Data Source:  BioPlex
RAB6C
Tbio
Family:  Enzyme
Novelty:  0.08908467
p_int:  0.781366958
p_ni:  0.218633042
Score:  0.245
Data Source:  BioPlex,STRINGDB
ARF6
Tbio
Family:  Enzyme
Novelty:  0.00278138
Score:  0.99
Data Source:  STRINGDB
ARF1
Tchem
Family:  Enzyme
Novelty:  0.00208554
Score:  0.972
Data Source:  STRINGDB
EGFR
Tclin
Family:  Kinase
Novelty:  0.00007274
Score:  0.935
Data Source:  STRINGDB
EGF
Tbio
Novelty:  0.00010809
Score:  0.917
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
88
electrocardiography
1
1
14
59
creatine kinase measurement
1
1
1
45.7
body mass index
1
1
1
42.3
neutrophil count
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
88
electrocardiography
14
59
creatine kinase measurement
1
45.7
body mass index
1
42.3
neutrophil count
1
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
IQ motif and Sec7 domain 1
VGNC:6297
460188
Macaque
IQ motif and Sec7 domain 1
693922
Mouse
MGI:1196356
232227
Dog
IQ motif and Sec7 domain 1
VGNC:42083
100683208
Horse
IQ motif and Sec7 domain 1
VGNC:19123
100055011
Species
Name
OMA
EggNOG
Inparanoid
Chimp
IQ motif and Sec7 domain 1
Macaque
IQ motif and Sec7 domain 1
Mouse
Dog
IQ motif and Sec7 domain 1
Horse
IQ motif and Sec7 domain 1
Publication Statistics
PubMed Score 24.06
PubMed score by year
PubTator Score 16.92
PubTator score by year
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Related Publications
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PMID
Year
Title