Tbio IQSEC1 IQ motif and SEC7 domain-containing protein 1

Protein Summary

Description

Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin.

Uniprot Accession IDs

• Q6DN90
• O94863
• Q96D85

Gene Name

• IQSEC1

Ensembl ID

• ENST00000273221
• ENSP00000273221
• ENSG00000144711

Symbol

• ARFGEP100
• BRAG2
• KIAA0763
• BRAG2
• GEP100
• ARFGEP100
• ARF-GEP100

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
microRNA	0.8
interacting protein	0.75
protein domain	0.73
drug perturbation	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.48   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 38   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.48   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0