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Tbio
PLAG1
Zinc finger protein PLAG1

Protein Summary
Description
Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia. Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involvi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316981
  • ENSP00000325546
  • ENSG00000181690
  • ENST00000423799
  • ENSP00000404067
  • ENST00000429357
  • ENSP00000416537

Symbol
  • PSA
  • SGPA
  • ZNF912
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.99
histone modification site profile
0.89
molecular function
0.84
biological process
0.74
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.83   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.83   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (16)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (59)
1 – 10 of 59
CHCHD7
Tdark
Novelty: 0.03976708
Score: 0.842
Data Source: STRINGDB
CHURC1
Tbio
Novelty: 0.00494162
Score: 0.8
Data Source: STRINGDB
HMGA2
Tbio
Family: TF
Novelty: 0.00091535
Score: 0.791
Data Source: STRINGDB
LCORL
Tbio
Family: TF
Novelty: 0.03738937
Score: 0.735
Data Source: STRINGDB
SDR16C5
Tbio
Family: Enzyme
Novelty: 0.19924793
Score: 0.73
Data Source: STRINGDB
TCEA1
Tbio
Novelty: 0.00218057
Score: 0.721
Data Source: STRINGDB
NCAPG
Tbio
Novelty: 0.02311432
Score: 0.716
Data Source: STRINGDB
IGF2
Tbio
Novelty: 0.00024884
Score: 0.711
Data Source: STRINGDB
KPNA2
Tbio
Novelty: 0.00784264
Score: 0.685
Data Source: STRINGDB
XKR4
Tbio
Novelty: 0.13476158
Score: 0.681
Data Source: STRINGDB
Publication Statistics
PubMed Score  124.83

PubMed score by year
PubTator Score  103.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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