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Tbio
ATL3
Atlastin-3

Protein Summary
Description
GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (PubMed:18270207, PubMed:19665976, PubMed:27619977). This gene encodes a member of a family of dynamin-like, integral membrane GTPases. The encoded protein is required for the proper formation of the network of interconnected tubules of the endoplasmic reticulum. Mutations in this gene may be associated with hereditary sensory neuropathy type IF. Alternatively spliced transcript variants that encode distinct isoforms have been described. [provided by RefSeq, Feb 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398868
  • ENSP00000381844
  • ENSG00000184743

Symbol
  • HSN1F
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
molecular function
0.93
transcription factor binding site profile
0.81
virus perturbation
0.79
transcription factor
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.26   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 216   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.26   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (58)
1 – 10 of 58
GALNT8
Tbio
Family:  Enzyme
Novelty:  0.19956817
p_int:  0.999993665
p_ni:  0.000006335
Data Source:  BioPlex
HS3ST3B1
Tbio
Family:  Enzyme
Novelty:  0.08796166
p_int:  0.99996092
p_ni:  0.00003908
Data Source:  BioPlex
RTN4
Tbio
Novelty:  0.00080371
p_int:  0.999715129
p_ni:  0.000284871
Score:  0.717
Data Source:  BioPlex,STRINGDB
LPAR4
Tchem
Family:  GPCR
Novelty:  0.02200758
p_int:  0.998749039
p_ni:  0.001250961
Data Source:  BioPlex
CD70
Tbio
Novelty:  0.00420393
p_int:  0.997111152
p_ni:  0.002858053
p_wrong:  0.000030795
Data Source:  BioPlex
RGL1
Tbio
Novelty:  0.0095933
p_int:  0.9936165
p_ni:  0.006383405
p_wrong:  9.5e-8
Data Source:  BioPlex
ADGRG5
Tdark
Family:  GPCR
Novelty:  0.26575982
p_int:  0.987973028
p_ni:  0.012026743
p_wrong:  2.28e-7
Data Source:  BioPlex
ANAPC5
Tbio
Family:  Enzyme
Novelty:  0.02102572
p_int:  0.974092589
p_ni:  0.025906565
p_wrong:  8.46e-7
Data Source:  BioPlex
HS3ST2
Tbio
Family:  Enzyme
Novelty:  0.0611326
p_int:  0.950809984
p_ni:  0.049189922
p_wrong:  9.4e-8
Score:  0.183
Data Source:  BioPlex,STRINGDB
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
p_int:  0.947550182
p_ni:  0.052449121
p_wrong:  6.96e-7
Data Source:  BioPlex
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
uric acid measurement
1
1
1
53.2
urate measurement
1
1
2
49.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
uric acid measurement
1
53.2
urate measurement
2
49.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
atlastin GTPase 3
VGNC:3204
451280
Macaque
atlastin GTPase 3
722170
Mouse
MGI:1924270
109168
Rat
RGD:1309871
309187
Dog
atlastin GTPase 3
VGNC:38232
476044
Species
Name
OMA
EggNOG
Inparanoid
Chimp
atlastin GTPase 3
Macaque
atlastin GTPase 3
Mouse
Rat
Dog
atlastin GTPase 3
Publication Statistics
PubMed Score 20.26
PubMed score by year
PubTator Score 10.34
PubTator score by year