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Tdark
SP5
Transcription factor Sp5

Protein Summary
Description
Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375281
  • ENSP00000364430
  • ENSG00000204335
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.71
PubMedID
0.64
transcription factor binding site profile
0.64
transcription factor
0.63
tissue sample
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.56   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 39   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.56   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (16)
MMP28
Tbio
Family:  Enzyme
Novelty:  0.01679444
Score:  0.805
Data Source:  STRINGDB
CHAC2
Tbio
Family:  Enzyme
Novelty:  0.14706039
Score:  0.757
Data Source:  STRINGDB
UBR3
Tbio
Family:  Enzyme
Novelty:  0.14930754
Score:  0.698
Data Source:  STRINGDB
LINGO2
Tbio
Novelty:  0.06112205
Score:  0.687
Data Source:  STRINGDB
MMP19
Tbio
Family:  Enzyme
Novelty:  0.01407961
Score:  0.63
Data Source:  STRINGDB
ASB3
Tbio
Novelty:  0.15921018
Score:  0.599
Data Source:  STRINGDB
EMX2
Tbio
Family:  TF
Novelty:  0.0064759
Score:  0.582
Data Source:  STRINGDB
OTX2
Tbio
Family:  TF
Novelty:  0.0024536
Score:  0.568
Data Source:  STRINGDB
ZBTB4
Tbio
Family:  TF
Novelty:  0.06984344
Score:  0.526
Data Source:  STRINGDB
PDE9A
Tchem
Family:  Enzyme
Novelty:  0.01862532
Score:  0.525
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lobe attachment
3
4
4
93.1
mathematical ability
3
2
3
71.2
cognitive function measurement
3
2
3
56.8
self reported educational attainment
1
1
1
33.1
intelligence
1
1
0
5.8
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lobe attachment
4
93.1
mathematical ability
3
71.2
cognitive function measurement
3
56.8
self reported educational attainment
1
33.1
intelligence
0
5.8
27.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Sp5 transcription factor
VGNC:50743
736052
Macaque
Sp5 transcription factor
693989
Mouse
MGI:1927715
64406
Rat
RGD:1308499
296510
Dog
Sp5 transcription factor
VGNC:46688
609211
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Sp5 transcription factor
Macaque
Sp5 transcription factor
Mouse
Rat
Dog
Sp5 transcription factor
Publication Statistics
PubMed Score 3.56
PubMed score by year
PubTator Score 50.69
PubTator score by year
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Related Publications
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PMID
Year
Title